Circadian- and temperature-specific effects of early deprivation on rat maternal care and pup development: Short-term markers for long-term effects

Daniela Rüedi-Bettschen, Joram Feldon, Christopher R. Pryce

Research output: Contribution to journalArticlepeer-review

Abstract

We compare the effects on pup body weight and on maternal care of 4-hr separation from dam and littermates on postnatal Days 1 to 14 (early deprivation, ED) under different thermal and circadian conditions. ED was performed at either 21° C (Cold), or 32° C (Warm), and either during the light or dark phase. The comparison group was nonhandling (NH), either under a nonreversed (Light) or reversed (Dark) cycle. At weaning, Cold ED pups were of lower body weight than Warm ED pups, and Warm ED pups were of lower body weight than NH pups. Light and Dark ED pups received high care at reunion relative to NH, and Cold ED pups received higher care at several hours postreunion relative to Warm ED and NH pups. We propose that reduced pup weight and increased maternal care are short-term markers for the severity of Cold ED, and that this manipulation could therefore impact negatively on emotionality and cognition in adulthood.

Original languageEnglish
Pages (from-to)59-71
Number of pages13
JournalDevelopmental Psychobiology
Volume45
Issue number2
DOIs
StatePublished - 2004
Externally publishedYes

Keywords

  • Circadian phase
  • Early deprivation
  • Maternal care
  • Neurodevelopmental model
  • Nonhandling
  • Pup physiology
  • Rat
  • Temperature

Fingerprint

Dive into the research topics of 'Circadian- and temperature-specific effects of early deprivation on rat maternal care and pup development: Short-term markers for long-term effects'. Together they form a unique fingerprint.

Cite this