Cigarette smoking and hormones

Lilach Marom-Haham, Adrian Shulman

Research output: Contribution to journalReview articlepeer-review


Purpose of review The purpose is to provide a summary of the effects of cigarette smoking on steroid hormone metabolism and how it affects female fertility. Recent findings Components of tobacco smoke such as polycyclic aromatic hydrocarbons lead to transcriptional upregulation of a number of genes, including members of the cytochrome P450 (CYP) family, in particular CYP1B1 and CYP1A1. In humans, CYP1A1 and CYP1A2 are the primary enzymes catalyzing the 2-hydroxylation of estradiol. This pathway shunts available estrogen away from the more estrogenically potent 16α-hydroxylation to the production of catechol estrogens, mainly 2 and 4 hydroxyestradiol. Summary Smoking has multiple effects on hormone secretion and metabolism. These effects are mainly mediated by the pharmacological action of tobacco alkaloids (nicotine and its metabolite cotinine). A strong body of evidence indicates that the negative effects of cigarette smoking on fertility compromises nearly every system involved in the reproductive process.

Original languageEnglish
Pages (from-to)230-235
Number of pages6
JournalCurrent Opinion in Obstetrics and Gynecology
Issue number4
StatePublished - 1 Aug 2016
Externally publishedYes


  • cotinine
  • estrogen
  • lifestyle
  • nicotine


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