Chronotoxicity and phenotypic variability

I. E. Ashkenazi; L. Peleg; Y. Cohen-Kitay; R. Carlebach

Chronotoxicity and phenotypic variability

I. E. Ashkenazi, L. Peleg, Y. Cohen-Kitay, R. Carlebach

Clinical Departments

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The chronotoxicity of anticancer drugs was studied in C57BL/6J mice. Cisplatinum (Cis), Adriamycin (Adria), and Cyclophosphamide (Cyclo) were injected, separately, at four circadian stages to groups of mice. Toxicity was monitored by body-weight and mortality. The results were compared to those of a parallel study with BALB/c strain (recently reported). Cyclo induced minute body-weight changes in both strains. Adria did not produce significant body-weight loss in BALB/c while a significant time dependency of body-weight loss was affected in C57BL/6J. Both strains did exhibit significant, but different, time dependent patterns of body-weight loss and recovery following Cis administration. In C57BL/6J chronomortality was affected by Cis and Cyclo and time dependent mortality was caused by Adria. None of the drugs had caused any lethal effects in BALB/c.

Original language	English
Pages (from-to)	241-244
Number of pages	4
Journal	Annual Review of Chronopharmacology
Volume	7
State	Published - 1990

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title = "Chronotoxicity and phenotypic variability",

abstract = "The chronotoxicity of anticancer drugs was studied in C57BL/6J mice. Cisplatinum (Cis), Adriamycin (Adria), and Cyclophosphamide (Cyclo) were injected, separately, at four circadian stages to groups of mice. Toxicity was monitored by body-weight and mortality. The results were compared to those of a parallel study with BALB/c strain (recently reported). Cyclo induced minute body-weight changes in both strains. Adria did not produce significant body-weight loss in BALB/c while a significant time dependency of body-weight loss was affected in C57BL/6J. Both strains did exhibit significant, but different, time dependent patterns of body-weight loss and recovery following Cis administration. In C57BL/6J chronomortality was affected by Cis and Cyclo and time dependent mortality was caused by Adria. None of the drugs had caused any lethal effects in BALB/c.",

author = "Ashkenazi, {I. E.} and L. Peleg and Y. Cohen-Kitay and R. Carlebach",

year = "1990",

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TY - JOUR

T1 - Chronotoxicity and phenotypic variability

AU - Ashkenazi, I. E.

AU - Peleg, L.

AU - Cohen-Kitay, Y.

AU - Carlebach, R.

PY - 1990

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N2 - The chronotoxicity of anticancer drugs was studied in C57BL/6J mice. Cisplatinum (Cis), Adriamycin (Adria), and Cyclophosphamide (Cyclo) were injected, separately, at four circadian stages to groups of mice. Toxicity was monitored by body-weight and mortality. The results were compared to those of a parallel study with BALB/c strain (recently reported). Cyclo induced minute body-weight changes in both strains. Adria did not produce significant body-weight loss in BALB/c while a significant time dependency of body-weight loss was affected in C57BL/6J. Both strains did exhibit significant, but different, time dependent patterns of body-weight loss and recovery following Cis administration. In C57BL/6J chronomortality was affected by Cis and Cyclo and time dependent mortality was caused by Adria. None of the drugs had caused any lethal effects in BALB/c.

AB - The chronotoxicity of anticancer drugs was studied in C57BL/6J mice. Cisplatinum (Cis), Adriamycin (Adria), and Cyclophosphamide (Cyclo) were injected, separately, at four circadian stages to groups of mice. Toxicity was monitored by body-weight and mortality. The results were compared to those of a parallel study with BALB/c strain (recently reported). Cyclo induced minute body-weight changes in both strains. Adria did not produce significant body-weight loss in BALB/c while a significant time dependency of body-weight loss was affected in C57BL/6J. Both strains did exhibit significant, but different, time dependent patterns of body-weight loss and recovery following Cis administration. In C57BL/6J chronomortality was affected by Cis and Cyclo and time dependent mortality was caused by Adria. None of the drugs had caused any lethal effects in BALB/c.

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SN - 0743-9539

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EP - 244

JO - Annual Review of Chronopharmacology

JF - Annual Review of Chronopharmacology

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Chronotoxicity and phenotypic variability

Abstract

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