Chronotoxicity and phenotypic variability

I. E. Ashkenazi, L. Peleg, Y. Cohen-Kitay, R. Carlebach

Research output: Contribution to journalArticlepeer-review


The chronotoxicity of anticancer drugs was studied in C57BL/6J mice. Cisplatinum (Cis), Adriamycin (Adria), and Cyclophosphamide (Cyclo) were injected, separately, at four circadian stages to groups of mice. Toxicity was monitored by body-weight and mortality. The results were compared to those of a parallel study with BALB/c strain (recently reported). Cyclo induced minute body-weight changes in both strains. Adria did not produce significant body-weight loss in BALB/c while a significant time dependency of body-weight loss was affected in C57BL/6J. Both strains did exhibit significant, but different, time dependent patterns of body-weight loss and recovery following Cis administration. In C57BL/6J chronomortality was affected by Cis and Cyclo and time dependent mortality was caused by Adria. None of the drugs had caused any lethal effects in BALB/c.

Original languageEnglish
Pages (from-to)241-244
Number of pages4
JournalAnnual Review of Chronopharmacology
StatePublished - 1990


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