The chronotoxicity of anticancer drugs was studied in C57BL/6J mice. Cisplatinum (Cis), Adriamycin (Adria), and Cyclophosphamide (Cyclo) were injected, separately, at four circadian stages to groups of mice. Toxicity was monitored by body-weight and mortality. The results were compared to those of a parallel study with BALB/c strain (recently reported). Cyclo induced minute body-weight changes in both strains. Adria did not produce significant body-weight loss in BALB/c while a significant time dependency of body-weight loss was affected in C57BL/6J. Both strains did exhibit significant, but different, time dependent patterns of body-weight loss and recovery following Cis administration. In C57BL/6J chronomortality was affected by Cis and Cyclo and time dependent mortality was caused by Adria. None of the drugs had caused any lethal effects in BALB/c.
|Number of pages||4|
|Journal||Annual Review of Chronopharmacology|
|State||Published - 1990|