TY - JOUR
T1 - Chronic urticaria and the metabolic syndrome
T2 - a cross-sectional community-based study of 11 261 patients
AU - Shalom, G.
AU - Magen, E.
AU - Babaev, M.
AU - Tiosano, S.
AU - Vardy, D. A.
AU - Linder, D.
AU - Horev, A.
AU - Saadia, A.
AU - Comaneshter, D.
AU - Agmon-Levin, N.
AU - Cohen, A. D.
N1 - Publisher Copyright:
© 2017 European Academy of Dermatology and Venereology
PY - 2018/2
Y1 - 2018/2
N2 - Background: Emerging evidence suggests that chronic urticaria (CU) is associated with chronic, low-grade, inflammatory process. Objective: To evaluate the association between CU and metabolic syndrome and its components in a large community-based medical database. Methods: A cross-sectional study of CU patients and matched controls was performed. CU was defined as eight urticaria diagnoses (with each two diagnoses registered within a period of 6 weeks) from 2002 to 2012. Data regarding the prevalence of metabolic syndrome, its components and possible complications were collected. Results: The study included 11 261 patients with CU and 67 216 controls. In a univariate analysis, CU was significantly associated with higher body mass index (BMI) and a higher prevalence of obesity, diabetes, hyperlipidaemia, hypertension, metabolic syndrome, chronic renal failure and gout. Multivariate analysis demonstrated a significant association between CU and metabolic syndrome (OR = 1.12, 95% CI 1.1–1.2, P < 0.001) and its components – obesity (OR = 1.2, 95% CI 1.1–1.3, P < 0.001), diabetes (OR = 1.08, 95% CI 1.01–1.15, P = 0.001), hyperlipidaemia (OR = 1.2, 95% CI 1.1–1.2, P < 0.001) and hypertension (OR = 1.1, 95% CI 1.1–1.2, P < 0.001). Conclusions: CU patients may have one or more undiagnosed components of metabolic syndrome despite their young age. Thus, appropriate targeted screening is advised.
AB - Background: Emerging evidence suggests that chronic urticaria (CU) is associated with chronic, low-grade, inflammatory process. Objective: To evaluate the association between CU and metabolic syndrome and its components in a large community-based medical database. Methods: A cross-sectional study of CU patients and matched controls was performed. CU was defined as eight urticaria diagnoses (with each two diagnoses registered within a period of 6 weeks) from 2002 to 2012. Data regarding the prevalence of metabolic syndrome, its components and possible complications were collected. Results: The study included 11 261 patients with CU and 67 216 controls. In a univariate analysis, CU was significantly associated with higher body mass index (BMI) and a higher prevalence of obesity, diabetes, hyperlipidaemia, hypertension, metabolic syndrome, chronic renal failure and gout. Multivariate analysis demonstrated a significant association between CU and metabolic syndrome (OR = 1.12, 95% CI 1.1–1.2, P < 0.001) and its components – obesity (OR = 1.2, 95% CI 1.1–1.3, P < 0.001), diabetes (OR = 1.08, 95% CI 1.01–1.15, P = 0.001), hyperlipidaemia (OR = 1.2, 95% CI 1.1–1.2, P < 0.001) and hypertension (OR = 1.1, 95% CI 1.1–1.2, P < 0.001). Conclusions: CU patients may have one or more undiagnosed components of metabolic syndrome despite their young age. Thus, appropriate targeted screening is advised.
UR - http://www.scopus.com/inward/record.url?scp=85029523579&partnerID=8YFLogxK
U2 - 10.1111/jdv.14548
DO - 10.1111/jdv.14548
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C2 - 28846167
AN - SCOPUS:85029523579
SN - 0926-9959
VL - 32
SP - 276
EP - 281
JO - Journal of the European Academy of Dermatology and Venereology
JF - Journal of the European Academy of Dermatology and Venereology
IS - 2
ER -