Chronic ultra-low dose follicle-stimulating hormone regimen for patients with polycystic ovary syndrome: one click, one follicle, one pregnancy

Raoul Orvieto, Roy Homburg

Research output: Contribution to journalArticlepeer-review

Abstract

In the present study we demonstrate that using a weekly incremental dose as small as 8.3 IU of FSH in a chronic ultra low-dose step-up protocol for anovulatory polycystic ovary syndrome (PCOS) produces very good clinical results with an excellent safety profile. Although using a significantly lower incremental (16.6% of the initial dose) and total (622 ± 286 IU) gonadotropin dose, compared with the widely used and accepted low-dose gonadotropins regimen, a clinical pregnancy rate (PR) of almost 30% per started cycle has been achieved with just one twin gestation and no case of even mild ovarian hyperstimulation syndrome (OHSS).

Original languageEnglish
Pages (from-to)1533-1535
Number of pages3
JournalFertility and Sterility
Volume91
Issue number4 SUPPL.
DOIs
StatePublished - Apr 2009
Externally publishedYes

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