Chronic treatment with haloperidol affect the response of the brain to pentobarbital

J. Yanai, C. G. Pick, Carmela Iser-Strenger

Research output: Contribution to journalArticlepeer-review

Abstract

Treatment of mice with haloperidol increased the number of dopamine D2 receptors (Bmax). The animals were given 40 or 50 mg of pentobarbital. Animals treated with haloperidol had a shorter duration of narcosis induced by pentobarbital than the controls, suggesting a decreased sensitivity to pentobarbital which was functional (CNS), since the animals treated with haloperidol had higher levels of pentobarbital in the brain upon awakening than the controls. The results suggest that increased Bmax reduces the sensitivity of the brain to pentobarbital.

Original languageEnglish
Pages (from-to)943-945
Number of pages3
JournalNeuropharmacology
Volume25
Issue number8
DOIs
StatePublished - Aug 1986
Externally publishedYes

Keywords

  • dopamine receptor number
  • haloperidol
  • mice narcosis
  • pentobarbital sensitivity

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