Chronic stimulation of the immune system in sarcoidosis and monoclonal gammopathy of undetermined significance

Tomer Saad, Nancy Agmon-Levin, Yehuda Shoenfeld

Research output: Contribution to journalArticlepeer-review

Abstract

Sarcoidosis is a systemic granulomatous disease which predominantly involves the lungs. Monoclonal gammopathy of undetermined significance (MGUS) characterized by clonal proliferation of plasma cells, can develop into multiple myeloma at a later stage. Although the cause of sarcoidosis remains unknown, the most likely etiology relates to chronic stimulation of the immune system that may result in polyclonal B cell proliferation. In some patients this polyclonal proliferation may develop into a monoclonal B-cell proliferation and induce the appearance of monoclonal gammopathy. In this article, a possible linkage between sarcoidosis and MGUS is raised, based on the case study of a 67-year-old woman and a review of the literature.

Original languageEnglish
Pages (from-to)809-810, 857, 856
JournalHarefuah
Volume148
Issue number12
StatePublished - Dec 2009
Externally publishedYes

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