Chronic myelomonocytic leukemia associated with primary amyloidosis

Amos M. Cohen*, Moshe Mittelman, Rivka Gal, Marisa Halperin, Meir Djaldetti

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

A case of chronic myelomonocytic leukemia (CMML) associated with primary amyloidosis (AL) is presented. Hepatosplenomegaly, macroglossia, and xanthelasma were the major physical findings. Laboratory tests showed macrocytic anemia, thrombocytopenia, monocytosis and a bi-clonal gammopathy. Early monocytes and monoblasts were noted in the bone marrow aspiration biopsy. Cytogenetic evaluation showed a clonal deletion of chromosome 21 long arm (21q-). Amyloid was present in the liver, tongue and xanthelasma. In addition, the patient was noted to have osteosclerosis of the lower extremities. Treatment with prednisone and colchicine resulted in a subjective response. The unusual association of CMML, and primary amyloidosis is discussed.

Original languageEnglish
Pages (from-to)183-187
Number of pages5
JournalLeukemia and Lymphoma
Volume16
Issue number1-2
DOIs
StatePublished - 1994

Keywords

  • Amyloidosis-complications
  • Chromosome 21 deletion
  • Chronic myelomonocytic leukemia
  • Xanthomatosis

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