TY - JOUR
T1 - Chronic myelomonocytic leukemia associated with primary amyloidosis
AU - Cohen, Amos M.
AU - Mittelman, Moshe
AU - Gal, Rivka
AU - Halperin, Marisa
AU - Djaldetti, Meir
PY - 1994
Y1 - 1994
N2 - A case of chronic myelomonocytic leukemia (CMML) associated with primary amyloidosis (AL) is presented. Hepatosplenomegaly, macroglossia, and xanthelasma were the major physical findings. Laboratory tests showed macrocytic anemia, thrombocytopenia, monocytosis and a bi-clonal gammopathy. Early monocytes and monoblasts were noted in the bone marrow aspiration biopsy. Cytogenetic evaluation showed a clonal deletion of chromosome 21 long arm (21q-). Amyloid was present in the liver, tongue and xanthelasma. In addition, the patient was noted to have osteosclerosis of the lower extremities. Treatment with prednisone and colchicine resulted in a subjective response. The unusual association of CMML, and primary amyloidosis is discussed.
AB - A case of chronic myelomonocytic leukemia (CMML) associated with primary amyloidosis (AL) is presented. Hepatosplenomegaly, macroglossia, and xanthelasma were the major physical findings. Laboratory tests showed macrocytic anemia, thrombocytopenia, monocytosis and a bi-clonal gammopathy. Early monocytes and monoblasts were noted in the bone marrow aspiration biopsy. Cytogenetic evaluation showed a clonal deletion of chromosome 21 long arm (21q-). Amyloid was present in the liver, tongue and xanthelasma. In addition, the patient was noted to have osteosclerosis of the lower extremities. Treatment with prednisone and colchicine resulted in a subjective response. The unusual association of CMML, and primary amyloidosis is discussed.
KW - Amyloidosis-complications
KW - Chromosome 21 deletion
KW - Chronic myelomonocytic leukemia
KW - Xanthomatosis
UR - http://www.scopus.com/inward/record.url?scp=0028569689&partnerID=8YFLogxK
U2 - 10.3109/10428199409114157
DO - 10.3109/10428199409114157
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AN - SCOPUS:0028569689
SN - 1042-8194
VL - 16
SP - 183
EP - 187
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 1-2
ER -