Chronic myeloid leukemia in solid organ transplant patients: a case series

Irina Amitai*, Adi Shacham Abulafia, Pia Raanani, Jeffrey H. Lipton

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Solid organ transplant (SOT) has transformed the survival and quality of life of patients with end-organ dysfunction. Lifelong need for immunosuppressive medications prolongs life expectancy, but results in altered immune function and is associated with a higher risk of certain malignancies, including chronic myeloid leukemia (CML). In this article, we report on six patients, aged 41–79 years, diagnosed with CML, from 3 to 132 months post-various organ transplants and treated with different tyrosine kinase inhibitors (TKI), including first generation (i.e., imatinib) and second generation (i.e., dasatinib and nilotinib). Use of second-generation TKIs has not been previously reported in this population. In these six cases, treatment with different TKIs in SOT patients was feasible, well tolerated and achieved good efficacy, which was maintained in extended follow-up, as well.

Original languageEnglish
Pages (from-to)214-218
Number of pages5
JournalInternational Journal of Hematology
Volume113
Issue number2
DOIs
StatePublished - Feb 2021

Keywords

  • Chronic myeloid leukemia
  • Dasatinib
  • Imatinib
  • Nilotinib
  • Solid organ transplant

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