Chronic myelogenous leukemia associated with extranodal b-cell lymphoma

Amos M. Cohen*, Moshe Mittelman, Judith Sandbank, Fiorela Shabtai, Mordechai Lapidot, Meir Djaldetti

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


A 75-year-old man is reported with a 10 year-history of villous adenoma of the colon and carcinoma in situ treated by hemicolectomy. Seven years later, he developed chronic myelogenous leukemia (CML). After a 3-month course of busulfan he was kept off chemotherapy for a one year period. Two years after the diagnosis of CML, an extranodal B-cell lymphoma developed in the left ankle region. A clonal pericentric inversion of chromosome 20 was shown in the lymphoma cells, but without Philadelphia (Ph' chromosome. The possible relation between the two malignant disorders is discussed in the light of current knowledge on the clonal origin of CML.

Original languageEnglish
Pages (from-to)287-291
Number of pages5
JournalLeukemia and Lymphoma
Issue number4
StatePublished - 1991
Externally publishedYes


  • Chronic myelogenous leukemia
  • Lymphoma
  • Multiple malignancies
  • Philadephia chromosome


Dive into the research topics of 'Chronic myelogenous leukemia associated with extranodal b-cell lymphoma'. Together they form a unique fingerprint.

Cite this