Chronic myelogenous leukemia associated with extranodal b-cell lymphoma

Amos M. Cohen, Moshe Mittelman, Judith Sandbank, Fiorela Shabtai, Mordechai Lapidot, Meir Djaldetti

Research output: Contribution to journalArticlepeer-review

Abstract

A 75-year-old man is reported with a 10 year-history of villous adenoma of the colon and carcinoma in situ treated by hemicolectomy. Seven years later, he developed chronic myelogenous leukemia (CML). After a 3-month course of busulfan he was kept off chemotherapy for a one year period. Two years after the diagnosis of CML, an extranodal B-cell lymphoma developed in the left ankle region. A clonal pericentric inversion of chromosome 20 was shown in the lymphoma cells, but without Philadelphia (Ph' chromosome. The possible relation between the two malignant disorders is discussed in the light of current knowledge on the clonal origin of CML.

Original languageEnglish
Pages (from-to)287-291
Number of pages5
JournalLeukemia and Lymphoma
Volume5
Issue number4
DOIs
StatePublished - 1991
Externally publishedYes

Keywords

  • Chronic myelogenous leukemia
  • Lymphoma
  • Multiple malignancies
  • Philadephia chromosome

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