TY - JOUR
T1 - Chronic myelogenous leukemia associated with extranodal b-cell lymphoma
AU - Cohen, Amos M.
AU - Mittelman, Moshe
AU - Sandbank, Judith
AU - Shabtai, Fiorela
AU - Lapidot, Mordechai
AU - Djaldetti, Meir
PY - 1991
Y1 - 1991
N2 - A 75-year-old man is reported with a 10 year-history of villous adenoma of the colon and carcinoma in situ treated by hemicolectomy. Seven years later, he developed chronic myelogenous leukemia (CML). After a 3-month course of busulfan he was kept off chemotherapy for a one year period. Two years after the diagnosis of CML, an extranodal B-cell lymphoma developed in the left ankle region. A clonal pericentric inversion of chromosome 20 was shown in the lymphoma cells, but without Philadelphia (Ph' chromosome. The possible relation between the two malignant disorders is discussed in the light of current knowledge on the clonal origin of CML.
AB - A 75-year-old man is reported with a 10 year-history of villous adenoma of the colon and carcinoma in situ treated by hemicolectomy. Seven years later, he developed chronic myelogenous leukemia (CML). After a 3-month course of busulfan he was kept off chemotherapy for a one year period. Two years after the diagnosis of CML, an extranodal B-cell lymphoma developed in the left ankle region. A clonal pericentric inversion of chromosome 20 was shown in the lymphoma cells, but without Philadelphia (Ph' chromosome. The possible relation between the two malignant disorders is discussed in the light of current knowledge on the clonal origin of CML.
KW - Chronic myelogenous leukemia
KW - Lymphoma
KW - Multiple malignancies
KW - Philadephia chromosome
UR - http://www.scopus.com/inward/record.url?scp=0026074867&partnerID=8YFLogxK
U2 - 10.3109/10428199109068139
DO - 10.3109/10428199109068139
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C2 - 27467852
AN - SCOPUS:0026074867
SN - 1042-8194
VL - 5
SP - 287
EP - 291
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 4
ER -