TY - JOUR
T1 - Chronic inflammation in FMF
T2 - Markers, risk factors, outcomes and therapy
AU - Ben-Zvi, Ilan
AU - Livneh, Avi
PY - 2011/2
Y1 - 2011/2
N2 - Familial Mediterranean fever (FMF) is the most common of the hereditary periodic fever syndromes. Although the typical clinical course of FMF is characterized by bouts of painful inflammation, this presentation represents only the tip of the iceberg. In many patients inflammation can persist in attack-free periods, as shown by high levels of acute-phase proteins, cytokines and inflammation-induced proteins. This subclinical inflammation puts patients at risk of developing complications such as anemia, splenomegaly, decreased bone mineral density, heart disease and life-threatening amyloid A amyloidosis, among others. In this article, we review the published data on markers and other factors involved in the persistence of inflammation in patients with FMF during attack-free periods, examine the risk factors for the development of this subclinical inflammation, summarize the complications of chronic inflammation in FMF and propose a new strategy for treatment, based on these data.
AB - Familial Mediterranean fever (FMF) is the most common of the hereditary periodic fever syndromes. Although the typical clinical course of FMF is characterized by bouts of painful inflammation, this presentation represents only the tip of the iceberg. In many patients inflammation can persist in attack-free periods, as shown by high levels of acute-phase proteins, cytokines and inflammation-induced proteins. This subclinical inflammation puts patients at risk of developing complications such as anemia, splenomegaly, decreased bone mineral density, heart disease and life-threatening amyloid A amyloidosis, among others. In this article, we review the published data on markers and other factors involved in the persistence of inflammation in patients with FMF during attack-free periods, examine the risk factors for the development of this subclinical inflammation, summarize the complications of chronic inflammation in FMF and propose a new strategy for treatment, based on these data.
UR - http://www.scopus.com/inward/record.url?scp=79651473433&partnerID=8YFLogxK
U2 - 10.1038/nrrheum.2010.181
DO - 10.1038/nrrheum.2010.181
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C2 - 21060333
AN - SCOPUS:79651473433
SN - 1759-4790
VL - 7
SP - 105
EP - 112
JO - Nature reviews. Rheumatology
JF - Nature reviews. Rheumatology
IS - 2
ER -