TY - JOUR
T1 - Chronic hepatitis C viral infection among SLE patients
T2 - the significance of coexistence
AU - Mahroum, Naim
AU - Hejly, Ashraf
AU - Tiosano, Shmuel
AU - Gendelman, Omer
AU - Comaneshter, Doron
AU - Cohen, Arnon D.
AU - Amital, Howard
N1 - Publisher Copyright:
© 2017, Springer Science+Business Media New York.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - The association between viral infection and autoimmune diseases is an established phenomenon in medicine. Hepatitis C viral infection is known to have such an association; however, its association with systemic lupus erythematosus has not been studied in a real life study driven from a large national database. The objective of this study was to investigate the association between SLE and chronic hepatitis C viral infection. Patients with SLE were compared with age- and sex-matched controls regarding the proportion chronic HCV infection. Chi-square and t tests were used for univariate analysis, and a logistic regression model was used for multivariate analysis. The study was performed utilizing the medical database of Clalit Health Services in Israel. There was a significant higher proportion of hepatitis C viral infection in SLE patients as compared to controls (1.06 and 0.39%, respectively; p < 0.001). A significant association was also observed among patients of higher socioeconomic status. In a multivariate logistic regression analysis, SLE was significantly associated with hepatitis C viral infection (OR = 2.07, 95% CI = 1.46–2.90). To conclude, Patients with SLE have a greater proportion of chronic HCV infection than matched controls.[MediaObject not available: see fulltext.].
AB - The association between viral infection and autoimmune diseases is an established phenomenon in medicine. Hepatitis C viral infection is known to have such an association; however, its association with systemic lupus erythematosus has not been studied in a real life study driven from a large national database. The objective of this study was to investigate the association between SLE and chronic hepatitis C viral infection. Patients with SLE were compared with age- and sex-matched controls regarding the proportion chronic HCV infection. Chi-square and t tests were used for univariate analysis, and a logistic regression model was used for multivariate analysis. The study was performed utilizing the medical database of Clalit Health Services in Israel. There was a significant higher proportion of hepatitis C viral infection in SLE patients as compared to controls (1.06 and 0.39%, respectively; p < 0.001). A significant association was also observed among patients of higher socioeconomic status. In a multivariate logistic regression analysis, SLE was significantly associated with hepatitis C viral infection (OR = 2.07, 95% CI = 1.46–2.90). To conclude, Patients with SLE have a greater proportion of chronic HCV infection than matched controls.[MediaObject not available: see fulltext.].
KW - Autoimmune disease
KW - Hepatitis C
KW - Infections
KW - SLE
UR - http://www.scopus.com/inward/record.url?scp=85010224340&partnerID=8YFLogxK
U2 - 10.1007/s12026-016-8886-7
DO - 10.1007/s12026-016-8886-7
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C2 - 28111706
AN - SCOPUS:85010224340
SN - 0257-277X
VL - 65
SP - 477
EP - 481
JO - Immunologic Research
JF - Immunologic Research
IS - 2
ER -
