Chronic eosinophilic leukemia complicated by epidural myeloblastoma

Alexander Dvilansky; Michael L. Alkan; Winston Ho; Helena Kaplan; Paskal Tiberin; Bracha Rachmilewitz

doi:10.1159/000208205

Chronic eosinophilic leukemia complicated by epidural myeloblastoma

Alexander Dvilansky, Michael L. Alkan, Winston Ho, Helena Kaplan, Paskal Tiberin, Bracha Rachmilewitz

Research output: Contribution to journal › Article › peer-review

Abstract

Epidural myeloblastoma, which compressed the spinal cord, was the first evidence for chronic granulocytic leukemia, eosinophilic type, Ph chromosome negative. This manifestation was preceded by 3 years follow-up of a patient with persistent eosinophilia of 60% mature eosinophils. The only clues for the diagnosis of leukemia were splenomegaly and high serum vitamin B₁₂, most of which was bound to transcobalamin I. The latter finding presents a useful diagnostic criterium in myeloproliferative disorders.

Original language	English
Pages (from-to)	356-361
Number of pages	6
Journal	Acta Haematologica
Volume	53
Issue number	6
DOIs	https://doi.org/10.1159/000208205
State	Published - 1975
Externally published	Yes

Keywords

Eosinophilic leukemia
Myeloblastoma
Transcobalamins
Vitamin B<inf>12</inf>

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10.1159/000208205

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AU - Kaplan, Helena

AU - Tiberin, Paskal

AU - Rachmilewitz, Bracha

PY - 1975

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N2 - Epidural myeloblastoma, which compressed the spinal cord, was the first evidence for chronic granulocytic leukemia, eosinophilic type, Ph chromosome negative. This manifestation was preceded by 3 years follow-up of a patient with persistent eosinophilia of 60% mature eosinophils. The only clues for the diagnosis of leukemia were splenomegaly and high serum vitamin B12, most of which was bound to transcobalamin I. The latter finding presents a useful diagnostic criterium in myeloproliferative disorders.

AB - Epidural myeloblastoma, which compressed the spinal cord, was the first evidence for chronic granulocytic leukemia, eosinophilic type, Ph chromosome negative. This manifestation was preceded by 3 years follow-up of a patient with persistent eosinophilia of 60% mature eosinophils. The only clues for the diagnosis of leukemia were splenomegaly and high serum vitamin B12, most of which was bound to transcobalamin I. The latter finding presents a useful diagnostic criterium in myeloproliferative disorders.

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KW - Myeloblastoma

KW - Transcobalamins

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Chronic eosinophilic leukemia complicated by epidural myeloblastoma

Abstract

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