Chronic eosinophilic leukemia complicated by epidural myeloblastoma

Alexander Dvilansky, Michael L. Alkan, Winston Ho, Helena Kaplan, Paskal Tiberin, Bracha Rachmilewitz

Research output: Contribution to journalArticlepeer-review


Epidural myeloblastoma, which compressed the spinal cord, was the first evidence for chronic granulocytic leukemia, eosinophilic type, Ph chromosome negative. This manifestation was preceded by 3 years follow-up of a patient with persistent eosinophilia of 60% mature eosinophils. The only clues for the diagnosis of leukemia were splenomegaly and high serum vitamin B12, most of which was bound to transcobalamin I. The latter finding presents a useful diagnostic criterium in myeloproliferative disorders.

Original languageEnglish
Pages (from-to)356-361
Number of pages6
JournalActa Haematologica
Issue number6
StatePublished - 1975
Externally publishedYes


  • Eosinophilic leukemia
  • Myeloblastoma
  • Transcobalamins
  • Vitamin B<inf>12</inf>


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