Chromosome Analysis of Oocytes in Stimulated Cycles

Georgiana Jagiello, Gabriel Oelsner, Eitan R. Barnea, Dalia Admon, Thomas J. Mikkelson, Alan H. Decherney, William H. James, Håakan Wramsby, Percy Liedholm, Karl Fredga

Research output: Contribution to journalLetterpeer-review


To the Editor: The article by Wramsby et al. (Jan. 15 issue),1 which described 11 of 23 oocytes recovered from 17 patients as abnormal, is worrisome. Such aneuploidy concerns physicians who use clomiphene administration and other methods in superovulation protocols in patients undergoing in vitro fertilization, as well as reproductive scientists who work with human oocytes. The sample size is small, although it is recognized that such material is difficult to obtain. Nevertheless, the results should be examined in the light of two larger studies of the chromosome complements of human oocytes. The first, published in 1968,2 described the method…

Original languageEnglish
Pages (from-to)318-319
Number of pages2
JournalNew England Journal of Medicine
Issue number5
StatePublished - 30 Jul 1987
Externally publishedYes


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