@article{3c732501234f49c9967d053f6c71706a,
title = "Chromosome 10q harbors a susceptibility locus for bipolar disorder in Ashkenazi Jewish families",
abstract = "We report the results of a 10 cM density genome-wide scan and further fine mapping of three chromosomal candidate regions in 10 Belgian multigenerational families with bipolar (BP) disorder. This two-stage approach revealed significant evidence for linkage on chromosome 10q21.3-10q22.3, showing a maximum multipoint parametric heterogeneity logarithm of odds (HLOD) score of 3.28 and a nonparametric linkage (NPL) score of 4.00. Most of the chromosome 10q evidence was derived from a single, large Ashkenazi Jewish pedigree. Haplotype analysis in this pedigree shows that the patients share a 14-marker haplotype, defining a chromosomal candidate region of 19.2 cM. This region was reported previously as a candidate region for BP disorder in several independent linkage analysis studies and in one large meta-analysis. It was also implicated in a linkage study on schizophrenia (SZ) in Ashkenazi Jewish families. Additionally, we found suggestive evidence for linkage on chromosome 19q13.2-13.4 (HLOD 2.01, NPL 1.09) and chromosome 7q21-q22 (HLOD 1.45, NPL 2.28). Together, these observations suggest that a gene located on chromosome 10q21.3-10q22.3 is underlying the susceptibility both for SZ and for BP disorder in at least the Ashkenazi Jewish population.",
keywords = "Affective disorders, Chromosome 10, Linkage analysis, Psychiatric genetics",
author = "T. Venken and M. Alaerts and D. Souery and D. Goossens and S. Sluijs and R. Navon and {Van Broeckhoven}, C. and J. Mendlewicz and J. Del-Favero and S. Claes",
note = "Funding Information: We thank the patients and their relatives for their cooperation and participation in this research study. The genome-wide genotyping was performed at G{\'e}n{\'e}thon (Evry, France) within the framework of the Scientific Program on {\textquoteleft}Molecular Neurobiology of Mental Illness{\textquoteright} financed by the European Science Foundation. We acknowledge the contribution of the personnel of the VIB Genetic Service Facility (http:// www.vibgeneticservicefacility.be/) to the genetic analyses. The Interuniversity Attraction Poles program P5/19 of the Federal Science Policy Office, the Fund for Scientific Research Flanders (FWO), and the Special Research Fund of the University of Antwerp (Belgium) have funded this work. MA has a PhD fellowship of FWO. SC is a Senior Clinical Researcher of the FWO.",
year = "2008",
month = apr,
doi = "10.1038/sj.mp.4002039",
language = "אנגלית",
volume = "13",
pages = "442--450",
journal = "Molecular Psychiatry",
issn = "1359-4184",
publisher = "Nature Publishing Group",
number = "4",
}