Chromosome 10q harbors a susceptibility locus for bipolar disorder in Ashkenazi Jewish families

T. Venken, M. Alaerts, D. Souery, D. Goossens, S. Sluijs, R. Navon, C. Van Broeckhoven, J. Mendlewicz, J. Del-Favero, S. Claes

Research output: Contribution to journalArticlepeer-review

Abstract

We report the results of a 10 cM density genome-wide scan and further fine mapping of three chromosomal candidate regions in 10 Belgian multigenerational families with bipolar (BP) disorder. This two-stage approach revealed significant evidence for linkage on chromosome 10q21.3-10q22.3, showing a maximum multipoint parametric heterogeneity logarithm of odds (HLOD) score of 3.28 and a nonparametric linkage (NPL) score of 4.00. Most of the chromosome 10q evidence was derived from a single, large Ashkenazi Jewish pedigree. Haplotype analysis in this pedigree shows that the patients share a 14-marker haplotype, defining a chromosomal candidate region of 19.2 cM. This region was reported previously as a candidate region for BP disorder in several independent linkage analysis studies and in one large meta-analysis. It was also implicated in a linkage study on schizophrenia (SZ) in Ashkenazi Jewish families. Additionally, we found suggestive evidence for linkage on chromosome 19q13.2-13.4 (HLOD 2.01, NPL 1.09) and chromosome 7q21-q22 (HLOD 1.45, NPL 2.28). Together, these observations suggest that a gene located on chromosome 10q21.3-10q22.3 is underlying the susceptibility both for SZ and for BP disorder in at least the Ashkenazi Jewish population.

Original languageEnglish
Pages (from-to)442-450
Number of pages9
JournalMolecular Psychiatry
Volume13
Issue number4
DOIs
StatePublished - Apr 2008

Keywords

  • Affective disorders
  • Chromosome 10
  • Linkage analysis
  • Psychiatric genetics

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