TY - JOUR
T1 - Chromosomal aberrations suggestive of mutagen-related leukemia after 21 years of "therapeutic" radon exposure
AU - Rechavi, Gideon
AU - Berkowicz, Miriam
AU - Rosner, Ester
AU - Neuman, Yoram
AU - Ben-Bassat, Isaac
AU - Ramot, Bracha
N1 - Funding Information:
We thank Dr. A. Werner for the helpful discussion. B. R. is the incumbent of the Dora and Gregorio Shapiro Chair for Hematologic Malignancies, Tel Aviv University, Sackler School of Medicine. This work is supported in part by the Irwin Edelstein Leukemia Research Fund, the Jakob and Judy Zemel Cancer Research Fund, the Maurits Van Beets Fund for Leukemia Research, and the Freda and Moise Eskenazy Fund for Cancer Research.
PY - 1990/8
Y1 - 1990/8
N2 - A 68-year-old woman with acute myelomonocytic leukemia, who was treated annually for 21 consecutive years by "therapeutic" low-dose radon gas radiation because of spondyloarthritis, is described. The karyotype of the malignant clone was 45,XX, -17, -18, del(5)(q15q33), +t(17;18)(q11.2q23). In 45% of the metaphases, the modal number was between hyperdiploid to near tetraploid. Double minute chromosomes were demonstrated in 60% of the cells. These chromosomal aberrations are suggestive of mutagen-related leukemia.
AB - A 68-year-old woman with acute myelomonocytic leukemia, who was treated annually for 21 consecutive years by "therapeutic" low-dose radon gas radiation because of spondyloarthritis, is described. The karyotype of the malignant clone was 45,XX, -17, -18, del(5)(q15q33), +t(17;18)(q11.2q23). In 45% of the metaphases, the modal number was between hyperdiploid to near tetraploid. Double minute chromosomes were demonstrated in 60% of the cells. These chromosomal aberrations are suggestive of mutagen-related leukemia.
UR - http://www.scopus.com/inward/record.url?scp=0025150090&partnerID=8YFLogxK
U2 - 10.1016/0165-4608(90)90225-Y
DO - 10.1016/0165-4608(90)90225-Y
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:0025150090
SN - 0165-4608
VL - 48
SP - 125
EP - 130
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 1
ER -
