Chromatin remodeling and transcriptional control of mesenchymal cells towards the osteogenic pathway

R. Marom, D. Benayahu

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Stem cell commitment and differentiation into specialized functional cells involves the coordinated activation of different sets of genes. Key players that control these processes in embryogenesis and adulthood are chromatin remodeling proteins and transcription factors. Tissue specific transcription factors direct the activation and regulation of lineage fate differentiation. Nevertheless these processes also depend on epigenetic regulation, namely-chromatin remodeling and structural changes that allow transcription factor-binding to functional elements at promoter sites. Understanding the mechanism of action of the different regulatory factors will allow resolving how chromatin remodeling and gene activation come together to regulate stem cell lineage fate decision. Consequently, one of the important challenges of today’s research is to characterize molecular pathways that coordinate the lineage specific function of such factors. In skeletal tissue, marrow stromal cells differentiate into osteoblasts under the well-coordinated action of bone specific regulators, such as Runx2 and Osterix, along with SWI/SNF (mating type switching/sucrose non fermenting) components, members of the CHD (chromodomain-helicase DNA binding) and HDAC (histone deacetylases) families of chromatin remodeling proteins. Recent studies demonstrate the functional interaction between chromatin remodeling and transcription factors during regulation of osteogenesis that was revealed using different cell culture and animal based models. Understanding the mechanisms of action of such factors will allow controlling cell differentiation, and utilizing stem cells for regenerative medicine of skeletal tissues.

Original languageEnglish
Title of host publicationStem Cells and Bone Tissue
PublisherCRC Press
Pages214-228
Number of pages15
ISBN (Electronic)9781466578425
ISBN (Print)9781466578418
DOIs
StatePublished - 1 Jan 2013

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