Chromatic multifocal pupillometer for objective early diagnosis of mild cognitive impairment

Ygal Rotenstreich, Daniel Ben-Ner, Inbal Sharvit-Ginon, Ramit Ravona-Springer, Michal Beeri, Ifat Sher

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


The pupil responses of 15 cognitively normal subjects (ages 60-74) were examined in response to 76 focal red and blue light stimuli using a chromatic multifocal pupillometer (CMP). Subjects with low cognitive scores as determined as by Montreal Cognitive Assessment testing, presented significantly weaker and sluggish pupil responses in peripheral and central locations of the visual field in response to red and blue light. Our findings suggests that the CMP may present a novel objective, non-invasive, low cost technique for early diagnosis of cognitive decline that may serve for Alzheimer Disease prevention and as sensitive outcome measure of therapeutic effects.

Original languageEnglish
Title of host publicationOpthalmic Technologies XXVII
EditorsPer G. Soderberg, Arthur Ho, Fabrice Manns
ISBN (Electronic)9781510605312
StatePublished - 2017
Event27th Conference on Ophthalmic Technologies - San Francisco, United States
Duration: 28 Jan 201729 Jan 2017

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


Conference27th Conference on Ophthalmic Technologies
Country/TerritoryUnited States
CitySan Francisco


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