TY - GEN
T1 - Chromatic multifocal pupillometer for objective early diagnosis of mild cognitive impairment
AU - Rotenstreich, Ygal
AU - Ben-Ner, Daniel
AU - Sharvit-Ginon, Inbal
AU - Ravona-Springer, Ramit
AU - Beeri, Michal
AU - Sher, Ifat
N1 - Publisher Copyright:
© 2017 SPIE.
PY - 2017
Y1 - 2017
N2 - The pupil responses of 15 cognitively normal subjects (ages 60-74) were examined in response to 76 focal red and blue light stimuli using a chromatic multifocal pupillometer (CMP). Subjects with low cognitive scores as determined as by Montreal Cognitive Assessment testing, presented significantly weaker and sluggish pupil responses in peripheral and central locations of the visual field in response to red and blue light. Our findings suggests that the CMP may present a novel objective, non-invasive, low cost technique for early diagnosis of cognitive decline that may serve for Alzheimer Disease prevention and as sensitive outcome measure of therapeutic effects.
AB - The pupil responses of 15 cognitively normal subjects (ages 60-74) were examined in response to 76 focal red and blue light stimuli using a chromatic multifocal pupillometer (CMP). Subjects with low cognitive scores as determined as by Montreal Cognitive Assessment testing, presented significantly weaker and sluggish pupil responses in peripheral and central locations of the visual field in response to red and blue light. Our findings suggests that the CMP may present a novel objective, non-invasive, low cost technique for early diagnosis of cognitive decline that may serve for Alzheimer Disease prevention and as sensitive outcome measure of therapeutic effects.
UR - http://www.scopus.com/inward/record.url?scp=85018906055&partnerID=8YFLogxK
U2 - 10.1117/12.2251428
DO - 10.1117/12.2251428
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AN - SCOPUS:85018906055
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Opthalmic Technologies XXVII
A2 - Soderberg, Per G.
A2 - Ho, Arthur
A2 - Manns, Fabrice
PB - SPIE
T2 - 27th Conference on Ophthalmic Technologies
Y2 - 28 January 2017 through 29 January 2017
ER -