Cholestatic jaundice: an immune response to prajmalium bitartrate

Heschi H. Rotmensch*, Israel Yust, Ella Livni, Meir Liron, Avraham Klejman, Tami Moalem, Alexander Gefel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Cholestatic jaundice associated with chills, pruritus and blood eosinophilia developed in a patient who received prajmalium bitartrate therapy for ventricular arrhythmia following acute myocardial infarction. Discontinuation of the drug resulted in a spontaneous improvement in the clinical and biochemical findings. Challenge by prajmalium bitartrate caused rapid reappearance of the clinical and biochemical features. In immunological studies, deposits of IgG and IgA were detected at the bile canaliculi by fluorescent staining, and the patient's lymphocytes produced macrophage migration inhibition after in vitro incubation with prajmalium bitartrate. Thus, laboratory results support the assumption of an allergic mechanism.

Original languageEnglish
Pages (from-to)738-741
Number of pages4
JournalPostgraduate Medical Journal
Issue number660
StatePublished - 1980


Dive into the research topics of 'Cholestatic jaundice: an immune response to prajmalium bitartrate'. Together they form a unique fingerprint.

Cite this