TY - JOUR
T1 - Cholestatic hepatitis induced by Epstein-Barr virus in a pediatric population
AU - Shkalim-Zemer, Vered
AU - Shahar-Nissan, Keren
AU - Ashkenazi-Hoffnung, Liat
AU - Amir, Jacob
AU - Bilavsky, Efraim
N1 - Publisher Copyright:
© 2015 SAGE Publications.
PY - 2015/10/11
Y1 - 2015/10/11
N2 - Objective. We present 5 cases of Epstein-Barr virus (EBV)-induced cholestatic hepatitis (CH) and review all additional pediatric cases from the literature. Design. The medical records of 5 patients with EBV-induced CH were reviewed. A comprehensive review of the literature was performed. Results. Including our patients, a total of 17 patients with EBV-induced CH were reviewed. The average age was 11 years (range 1-18 years); male to female ratio was 0.9:1. The most common presenting symptoms included fever, jaundice, and cervical lymphadenopathy. However, a significant number of patients presented with jaundice alone, without other suggestive signs of an EBV infection. Hepatocellular enzyme levels were significantly higher than in classical infectious mononucleosis. In many cases, serum alkaline phosphatase was also elevated, accompanied by direct hyperbilirubinemia. Conclusion. EBV infection should be included in the differential diagnosis of CH in all age groups. In the vast majority, full recovery is expected.
AB - Objective. We present 5 cases of Epstein-Barr virus (EBV)-induced cholestatic hepatitis (CH) and review all additional pediatric cases from the literature. Design. The medical records of 5 patients with EBV-induced CH were reviewed. A comprehensive review of the literature was performed. Results. Including our patients, a total of 17 patients with EBV-induced CH were reviewed. The average age was 11 years (range 1-18 years); male to female ratio was 0.9:1. The most common presenting symptoms included fever, jaundice, and cervical lymphadenopathy. However, a significant number of patients presented with jaundice alone, without other suggestive signs of an EBV infection. Hepatocellular enzyme levels were significantly higher than in classical infectious mononucleosis. In many cases, serum alkaline phosphatase was also elevated, accompanied by direct hyperbilirubinemia. Conclusion. EBV infection should be included in the differential diagnosis of CH in all age groups. In the vast majority, full recovery is expected.
KW - Epstein-Barr virus
KW - cholestatic hepatitis
KW - infectious mononucleosis
KW - jaundice
UR - http://www.scopus.com/inward/record.url?scp=84941216544&partnerID=8YFLogxK
U2 - 10.1177/0009922815570618
DO - 10.1177/0009922815570618
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AN - SCOPUS:84941216544
SN - 0009-9228
VL - 54
SP - 1153
EP - 1157
JO - Clinical Pediatrics
JF - Clinical Pediatrics
IS - 12
ER -
