TY - JOUR
T1 - Chlorpropamide Hyponatremia
AU - Epstein, S.
AU - Van Mieghem, W.
AU - Simson, E.
AU - Jackson, W. P.U.
AU - Gregerman, Robert I.
AU - Weissman, Peter N.
AU - Shenkman, Louis
PY - 1972/4/6
Y1 - 1972/4/6
N2 - To the Editor: An interesting report in the Journal by Weissman, Shenkman and Gregerman (N Engl J Med 284: 65–71, 1971) suggested that chlorpropamide therapy in diabetic patients could lead to serious hyponatremia on the basis of its antidiuretic activity (probably by potentiating the antidiuretic hormone). Five such patients were described, and a further three were found among 80 clinic subjects. We have measured the serum sodium levels in 406 patients with maturity-onset diabetes taking oral hypoglycemic drugs attending the Groote Schuur Hospital Diabetes Clinic, of whom 221 were on chlorpropamide, mostly 500 mg per day. In none was the. No extract is available for articles shorter than 400 words.
AB - To the Editor: An interesting report in the Journal by Weissman, Shenkman and Gregerman (N Engl J Med 284: 65–71, 1971) suggested that chlorpropamide therapy in diabetic patients could lead to serious hyponatremia on the basis of its antidiuretic activity (probably by potentiating the antidiuretic hormone). Five such patients were described, and a further three were found among 80 clinic subjects. We have measured the serum sodium levels in 406 patients with maturity-onset diabetes taking oral hypoglycemic drugs attending the Groote Schuur Hospital Diabetes Clinic, of whom 221 were on chlorpropamide, mostly 500 mg per day. In none was the. No extract is available for articles shorter than 400 words.
UR - http://www.scopus.com/inward/record.url?scp=0015495633&partnerID=8YFLogxK
U2 - 10.1056/NEJM197204062861423
DO - 10.1056/NEJM197204062861423
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AN - SCOPUS:0015495633
SN - 0028-4793
VL - 286
SP - 785
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 14
ER -