Chlormethine Gel for the Treatment of Skin Lesions in All Stages of Mycosis Fungoides Cutaneous T-Cell Lymphoma: A Narrative Review and International Experience

Larisa J. Geskin*, Martine Bagot, Emmilia Hodak, Ellen J. Kim

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Mycosis fungoides (MF), the most common form of primary cutaneous T-cell lymphoma, is a disease typically with an indolent course that is initially characterized by localized patches and plaques. In the early stages of the disease, treatment involves skin-directed therapies (SDTs) such as topical corticosteroids and retinoids. Chlormethine gel (also known as mechlorethamine) was the first SDT purposely developed to treat MF and is currently endorsed by international guidelines for the treatment of adult patients with MF as a first-line therapy. While chlormethine is an efficacious therapy, its usage may be complicated by the development of cutaneous reactions at the sites of application. Herein, we discuss the supportive guidelines for MF and the suitability of chlormethine as a therapeutic option in patients with MF. In addition, we present real-world experience on the use of chlormethine gel from clinics in the USA, Israel, and France with the aim of demonstrating the efficacy of chlormethine gel in routine clinical practice and outlining strategies that are being used to manage emergent cutaneous reactions.

Original languageEnglish
Pages (from-to)1085-1106
Number of pages22
JournalDermatology and Therapy
Volume11
Issue number4
DOIs
StatePublished - Aug 2021

Funding

FundersFunder number
Aptitude Health
Helsinn Healthcare SA
Innate Pharma
Takeda Pharmaceuticals U.S.A.
Kyowa Hakko Kirin

    Keywords

    • Chlormethine gel
    • Cutaneous T-cell lymphoma
    • Mycosis fungoides
    • Patient management
    • Real-world

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