Chiral modulation of amyloid beta fibrillation and cytotoxicity by enantiomeric carbon dots

Ravit Malishev, Elad Arad, Susanta Kumar Bhunia, Shira Shaham-Niv, Sofiya Kolusheva, Ehud Gazit, Raz Jelinek*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

97 Scopus citations

Abstract

Enantiomeric carbon dots (C-dots) synthesized from l-lysine or d-lysine, modulate aggregation and cytotoxicity of amyloid beta-42 (Aβ42), the primary constituent of the amyloid plaques associated with Alzheimer's disease. In particular, l-Lys-C-dots dramatically remodeled Aβ42 secondary structure and fibril morphologies, as well as inhibited Aβ42 cytotoxicity and membrane interactions.

Original languageEnglish
Pages (from-to)7762-7765
Number of pages4
JournalChemical Communications
Volume54
Issue number56
DOIs
StatePublished - 2018

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