TY - JOUR
T1 - Chiral modulation of amyloid beta fibrillation and cytotoxicity by enantiomeric carbon dots
AU - Malishev, Ravit
AU - Arad, Elad
AU - Bhunia, Susanta Kumar
AU - Shaham-Niv, Shira
AU - Kolusheva, Sofiya
AU - Gazit, Ehud
AU - Jelinek, Raz
N1 - Publisher Copyright:
© The Royal Society of Chemistry.
PY - 2018
Y1 - 2018
N2 - Enantiomeric carbon dots (C-dots) synthesized from l-lysine or d-lysine, modulate aggregation and cytotoxicity of amyloid beta-42 (Aβ42), the primary constituent of the amyloid plaques associated with Alzheimer's disease. In particular, l-Lys-C-dots dramatically remodeled Aβ42 secondary structure and fibril morphologies, as well as inhibited Aβ42 cytotoxicity and membrane interactions.
AB - Enantiomeric carbon dots (C-dots) synthesized from l-lysine or d-lysine, modulate aggregation and cytotoxicity of amyloid beta-42 (Aβ42), the primary constituent of the amyloid plaques associated with Alzheimer's disease. In particular, l-Lys-C-dots dramatically remodeled Aβ42 secondary structure and fibril morphologies, as well as inhibited Aβ42 cytotoxicity and membrane interactions.
UR - http://www.scopus.com/inward/record.url?scp=85049806998&partnerID=8YFLogxK
U2 - 10.1039/C8CC03235A
DO - 10.1039/C8CC03235A
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:85049806998
SN - 1359-7345
VL - 54
SP - 7762
EP - 7765
JO - Chemical Communications
JF - Chemical Communications
IS - 56
ER -