Childhood Pemphigus Foliaceus with Exclusive Immunoglobulin G Autoantibodies to Desmocollins

Shamir Geller, Andrea Gat, Avikam Harel, Jacob Mashiah, Tal Zeeli, Rüdiger Eming, Norito Ishii, Michael Hertl, Takashi Hashimoto, Eli Sprecher

Research output: Contribution to journalArticlepeer-review

Abstract

Pemphigus refers to a group of potentially fatal blistering skin diseases that are often due to the deleterious effects of autoantibodies directed against desmosomal antigens. Although desmogleins have been mainly implicated as autoantigens in pemphigus, a steadily growing body of evidence suggests that other desmosomal proteins may be causally involved as well. Antibodies directed against desmocollin-3 have been shown to play a direct role in the pathogenesis of several types of pemphigus. Here we describe the case of a child with localized pemphigus foliaceus and immunoglobulin G (IgG) reactivity exclusively directed to desmocollins. The present report suggests that autoantibodies against nondesmoglein antigens may play a role in the pathogenesis of superficial pemphigus, in addition to pemphigus vulgaris, paraneoplastic pemphigus, and IgA pemphigus.

Original languageEnglish
Pages (from-to)e10-e13
JournalPediatric Dermatology
Volume33
Issue number1
DOIs
StatePublished - 1 Jan 2016
Externally publishedYes

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