Childhood outcomes of neonates diagnosed with portal vein thrombosis

Iris Morag, Prakesh S. Shah, Monica Epelman, Alan Daneman, Tzipi Strauss, Aideen M. Moore

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: The study aims to determine childhood outcomes of neonates diagnosed with portal vein thrombosis (PVT). Methods: A retrospective chart review of neonates diagnosed with PVT who had documented follow up (physical examination, laboratory tests or ultrasonographic examination) at the age of 2 years or beyond was conducted. Results: Data were available for 70 children (71% of eligible neonates) at a median age of 5 years (range 2-8 years). Physical examination was unremarkable in all who were examined (n = 68). Twenty-five children had liver functions assessed and only mild abnormalities were detected in nine children. Six of 25 patients tested for thrombophilia showed abnormalities. Thirty-seven children had ultrasonographic follow up. Left lobar atrophy (LLA) was noted in 20 children (16 had isolated LLA, two had LLA and splenomegaly, and two had LLA and portal hypertension). Five children who had normal ultrasound examinations at discharge had splenomegaly (two with additional finding of LLA) at follow up. Two children with portal hypertension diagnosed during neonatal period needed porta-caval shunting. Conclusion: Our results show that among patients, who had PVT as neonates, 28% still had asymptomatic LLA in childhood, 7% had slowly progressive splenomegaly and 3% required shunting because of progression of portal hypertension. Ultrasonographic follow up was the most sensitive method in detecting progression associated with neonatal PVT. Until more data are available, periodic long-term ultrasonographic follow up should be considered for neonates diagnosed with PVT.

Original languageEnglish
Pages (from-to)356-360
Number of pages5
JournalJournal of Paediatrics and Child Health
Volume47
Issue number6
DOIs
StatePublished - Jun 2011
Externally publishedYes

Keywords

  • Gastroenterology
  • Neonatal
  • Neonatology
  • Outcome
  • Portal hypertension
  • Thrombosis

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