Childhood malignant thymoma: Clinical, therapeutic, and immunohistochemical considerations

Chaim Kaplinsky*, Celia Mor, Yacov Goshen, Isaac Yaniv, Hanah Tamary, Lutfi Jaber, Batia Stark, S. Stern, Rina Zaizov, Ian J. Cohen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Malignant thymomas are among the least common mediastinal tumors in the pediatric age group. Thymomas are considered malignant on the basis of macroscopic and microscopic invasiveness. As only 20 well-documented cases involving children have been reported in the literature, the pattern of responsiveness to therapy and the value of prognostic signs is obscure. Two cases of malignant pediatric thymomas are reported with pathognomonic histoimmunological features of aggressive thymoma. One was cured, with a follow-up of 70 months, and one died while on therapy. Analysis of the histological features and the immunoperoxidase staining displays the complexity of pediatric thymomas and the inability to prognosticate the outcome, respectively.

Original languageEnglish
Pages (from-to)261-268
Number of pages8
JournalPediatric Hematology and Oncology
Volume9
Issue number3
DOIs
StatePublished - 1992

Keywords

  • Immunochemistry
  • Malignant thymoma
  • Therapy

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