Chest wall shrapnel-induced beryllium-sensitization and associated pulmonary disease

Elizabeth Fireman, A. Bar Shai, Y. Lerman, M. Topihky, P. D. Blanc, L. Maier, L. Li, S. Chandra, J. M. Abraham, I. Fomin, G. Aviram, J. L. Abraham

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic beryllium disease (CBD) is an exposure-related granulomatous disease mimicking sarcoidosis. Beryllium exposure-associated disease occurs mainly via inhalation, but skin may also be a source of sensitization. A 65-year-old male with a history of war-related shrapnel wounds was initially diagnosed with pulmonary sarcoidosis. Twenty years later, the possibility of a metal-related etiology for the lung disease was raised. A beryllium lymphocyte proliferation test, elemental analysis of removed shrapnel, and genetic studies were consistent with a diagnosis of CBD. This case demonstrates that retained beryllium-containing foreign bodies can be linked to a pathophysiologic response in the lung consistent with CBD.

Original languageEnglish
Pages (from-to)147-150
Number of pages4
JournalSarcoidosis Vasculitis and Diffuse Lung Diseases
Volume29
Issue number2
StatePublished - 2012

Keywords

  • Beryllium sensitization
  • Chest wall
  • Shrapnel

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