Chemokines: Progress toward identifying molecular targets for therapeutic agents

O. M.Zack Howard, Adit Ben-Baruch, Joost J. Oppenheim

Research output: Contribution to journalReview articlepeer-review

Abstract

Leukocyte migration towards injury sites is directed by the interaction of chemokines with their receptors. The stages of migration are closely regulated events that involve chemokine-induced leukocyte adhesion, diapedesis and homing. Current research suggests a pathophysiological role for chemokines in diverse inflammatory states arising from viral, bacterial and parasitic infection, allergic and asthmatic reactions, atherosclerosis and arthritis. A role for chemokines in tumor immunity and angiogenesis has recently been demonstrated. A basis for the rational design of chemokine antagonists is emerging from a knowledge of tertiary structures and mutational analysis of chemokine ligands and receptors. Here, we discuss advances in knowledge about chemokine structure and function, with emphasis on potential therapeutic agents.

Original languageEnglish
Pages (from-to)46-51
Number of pages6
JournalTrends in Biotechnology
Volume14
Issue number2
DOIs
StatePublished - Feb 1996
Externally publishedYes

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