Chemokines and the inflammatory response following cardiopulmonary bypass - A new target for therapeutic intervention? - A review

Ron Ben-Abraham, Avi A. Weinbroum, Benjamin Dekel, Gideon Paret*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

This 10-year Medline search of English-language articles describing experimental and clinical studies on chemokines, cardiopulmonary bypass (CPB) and systemic or multiorgan failure revealed that chemokines are significantly involved in the pathogenesis of post-CPB syndrome. The post-CPB inflammatory response depends upon recruitment and activation of inflammatory cells. Leucocyte recruitment is a well-orchestrated process that involves several protein families, including pro-inflammatory cytokines, adhesion molecules and chemokines. Current anti-inflammatory therapies mostly act on the cells that have already been recruited. A more efficient therapy might be the prevention of excessive recruitment of particular leucocyte populations by antagonizing chemokine receptors which might act upstream of the current anti-inflammatory agents. The chemokines, which are a cytokine subfamily of chemotactic cytokines, participate in recognizing, recruiting, removing and repairing inflammation. As chemokines target specific leucocyte subsets, antagonism of a single chemokine ligand or receptor would be expected to have a circumscribed effect, thereby endowing the antagonist with a limited side-effect profile. Chemokines should be considered as possible targets for therapeutic intervention.

Original languageEnglish
Pages (from-to)655-661
Number of pages7
JournalPaediatric Anaesthesia
Volume13
Issue number8
DOIs
StatePublished - 2003
Externally publishedYes

Keywords

  • Cardiopulmonary bypass
  • Chemokines
  • Inflammatory response

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