Chemical Synthesis of Bioactive Proteins

Omer Harel, Muhammad Jbara*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

13 Scopus citations


Nature has developed a plethora of protein machinery to operate and maintain nearly every task of cellular life. These processes are tightly regulated via post-expression modifications—transformations that modulate intracellular protein synthesis, folding, and activation. Methods to prepare homogeneously and precisely modified proteins are essential to probe their function and design new bioactive modalities. Synthetic chemistry has contributed remarkably to protein science by allowing the preparation of novel biomacromolecules that are often challenging or impractical to prepare via common biological means. The ability to chemically build and precisely modify proteins has enabled the production of new molecules with novel physicochemical properties and programmed activity for biomedical research, diagnostic, and therapeutic applications. This minireview summarizes recent developments in chemical protein synthesis to produce bioactive proteins, with emphasis on novel analogs with promising in vitro and in vivo activity.

Original languageEnglish
Article numbere202217716
JournalAngewandte Chemie - International Edition
Issue number13
StatePublished - 20 Mar 2023


FundersFunder number
Neubauer Foundation
Tel Aviv University
Council for Higher Education


    • Bioactive Proteins
    • Chemical Protein Synthesis
    • Post-Translational Modifications
    • Protein Modification
    • Protein Semi-Synthesis


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