Chemical properties of myxococcus xanthus antibiotic ta

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Antibiotic TA was purified and crystallized from culture fluids of Myxococcus xanthus TA. The antibiotic (C34H57O9N, M.W. 623.8) contained the following functional groups: ketone, lactone, secondary amide, methoxy-substituted diene (λmax239 nm), primary alcohol and three secondary alcohols, two of which were cis-vicinal. Mild alkaline hydrolysis opened the lactone with concomitant loss of antibiotic activity. Periodate oxidation also destroyed biological activity.

Original languageEnglish
Pages (from-to)788-793
Number of pages6
JournalJournal of Antibiotics
Issue number7
StatePublished - 1982


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