TY - JOUR
T1 - Chemical properties of myxococcus xanthus antibiotic ta
AU - Rosenberg, Eugene
AU - Fytlovitch, Shlomo
AU - Carmeli, Shmuel
AU - Kashman, Yoel
PY - 1982
Y1 - 1982
N2 - Antibiotic TA was purified and crystallized from culture fluids of Myxococcus xanthus TA. The antibiotic (C34H57O9N, M.W. 623.8) contained the following functional groups: ketone, lactone, secondary amide, methoxy-substituted diene (λmax239 nm), primary alcohol and three secondary alcohols, two of which were cis-vicinal. Mild alkaline hydrolysis opened the lactone with concomitant loss of antibiotic activity. Periodate oxidation also destroyed biological activity.
AB - Antibiotic TA was purified and crystallized from culture fluids of Myxococcus xanthus TA. The antibiotic (C34H57O9N, M.W. 623.8) contained the following functional groups: ketone, lactone, secondary amide, methoxy-substituted diene (λmax239 nm), primary alcohol and three secondary alcohols, two of which were cis-vicinal. Mild alkaline hydrolysis opened the lactone with concomitant loss of antibiotic activity. Periodate oxidation also destroyed biological activity.
UR - http://www.scopus.com/inward/record.url?scp=0019974687&partnerID=8YFLogxK
U2 - 10.7164/antibiotics.35.788
DO - 10.7164/antibiotics.35.788
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AN - SCOPUS:0019974687
SN - 0021-8820
VL - 35
SP - 788
EP - 793
JO - Journal of Antibiotics
JF - Journal of Antibiotics
IS - 7
ER -