Chemical exchange saturation transfer by intermolecular double-quantum coherence

Wen Ling, Uzi Eliav, Gil Navon, Alexej Jerschow*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

A number of contrast enhancement effects based on the use of intermolecular multiple-quantum coherences, or distant dipolar field effects are known. This phenomenon is characterized by the dependence on the mth power of the initial magnetization (where m is the coherence order used). In this paper, we describe the contrast enhancement based on chemical exchange saturation transfer and NOE, which is achieved by the use of intermolecular double-quantum coherences (iDQC). The method was validated using clinically relevant systems based on glycosaminoglycans and a sample of cartilage tissue, showing that the CEST contrast, as well as, NOE are enhanced by iDQC.

Original languageEnglish
Pages (from-to)29-32
Number of pages4
JournalJournal of Magnetic Resonance
Volume194
Issue number1
DOIs
StatePublished - Sep 2008

Funding

FundersFunder number
New York State Office of Science, TechnologyP41 FM66354
National Science FoundationCHE-0554400
National Institutes of Health
National Institute of Arthritis and Musculoskeletal and Skin DiseasesR21AR054002
Israel Science Foundation

    Keywords

    • CEST
    • Chemical exchange saturation transfer
    • DDF
    • Distant dipolar field
    • Intermolecular multiple-quantum coherences
    • MRI
    • Nonlinear dynamics
    • iMQC

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