TY - JOUR
T1 - Chemical exchange saturation transfer by intermolecular double-quantum coherence
AU - Ling, Wen
AU - Eliav, Uzi
AU - Navon, Gil
AU - Jerschow, Alexej
N1 - Funding Information:
The spectroscopy work was supported by the US NSF, Grant CHE-0554400. The imaging and cartilage work was supported by the US NIH, Grant 1R21AR054002-01A1 and by the Israel Science Foundation grant to G.N. A.J. is a member of the New York Structural Biology Center, which is supported by the New York State Office of Science, Technology, and Academic Research and NIH Grant P41 FM66354.
PY - 2008/9
Y1 - 2008/9
N2 - A number of contrast enhancement effects based on the use of intermolecular multiple-quantum coherences, or distant dipolar field effects are known. This phenomenon is characterized by the dependence on the mth power of the initial magnetization (where m is the coherence order used). In this paper, we describe the contrast enhancement based on chemical exchange saturation transfer and NOE, which is achieved by the use of intermolecular double-quantum coherences (iDQC). The method was validated using clinically relevant systems based on glycosaminoglycans and a sample of cartilage tissue, showing that the CEST contrast, as well as, NOE are enhanced by iDQC.
AB - A number of contrast enhancement effects based on the use of intermolecular multiple-quantum coherences, or distant dipolar field effects are known. This phenomenon is characterized by the dependence on the mth power of the initial magnetization (where m is the coherence order used). In this paper, we describe the contrast enhancement based on chemical exchange saturation transfer and NOE, which is achieved by the use of intermolecular double-quantum coherences (iDQC). The method was validated using clinically relevant systems based on glycosaminoglycans and a sample of cartilage tissue, showing that the CEST contrast, as well as, NOE are enhanced by iDQC.
KW - CEST
KW - Chemical exchange saturation transfer
KW - DDF
KW - Distant dipolar field
KW - Intermolecular multiple-quantum coherences
KW - MRI
KW - Nonlinear dynamics
KW - iMQC
UR - http://www.scopus.com/inward/record.url?scp=49349108757&partnerID=8YFLogxK
U2 - 10.1016/j.jmr.2008.05.026
DO - 10.1016/j.jmr.2008.05.026
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AN - SCOPUS:49349108757
SN - 1090-7807
VL - 194
SP - 29
EP - 32
JO - Journal of Magnetic Resonance
JF - Journal of Magnetic Resonance
IS - 1
ER -