TY - JOUR
T1 - Chemerin is present in human cord blood and is positively correlated with birthweight
AU - Mazaki-Tovi, Shali
AU - Kasher-Meron, Michal
AU - Hemi, Rina
AU - Haas, Jigal
AU - Gat, Itai
AU - Lantsberg, Daniel
AU - Hendler, Israel
AU - Kanety, Hannah
N1 - Funding Information:
This study was supported by grants from the Mintz-Law Foundation of Tel-Aviv University and the Talpiot Medical Leadership Program , Sheba Medical Center, Tel Hashmer, Israel (all to S.M.-T.).
PY - 2012/11
Y1 - 2012/11
N2 - Objective: Chemerin, a novel adipokine, has been implicated in adipogenesis, inflammation, and metabolism. The aims of this study were to determine the presence of chemerin in cord blood and its association with birthweight. Study Design: This cross-sectional study included the following: (1) twins with (n = 24) or without (n = 28) birthweight discordancy; and (2) singletons subclassified into small-for-gestational-age (SGA; n = 18); appropriate for gestational age (AGA; n = 33); and large-for-gestational-age (LGA; n = 8). Cord blood chemerin was determined. Parametric and nonparametric statistics were used for analysis. Results: The results of the study included the following: (1) within the discordant twins group, the median chemerin concentration was significantly lower in the SGA group than in their cotwins; (2) within singletons, the median chemerin concentration was significantly higher in the LGA than the AGA newborns; and (3) the regression model revealed that chemerin was independently associated with birthweight. Conclusion: Cord blood chemerin is present in cord blood and its concentrations are positively correlated with birthweight. These novel findings support a role of adipokines in fetal growth.
AB - Objective: Chemerin, a novel adipokine, has been implicated in adipogenesis, inflammation, and metabolism. The aims of this study were to determine the presence of chemerin in cord blood and its association with birthweight. Study Design: This cross-sectional study included the following: (1) twins with (n = 24) or without (n = 28) birthweight discordancy; and (2) singletons subclassified into small-for-gestational-age (SGA; n = 18); appropriate for gestational age (AGA; n = 33); and large-for-gestational-age (LGA; n = 8). Cord blood chemerin was determined. Parametric and nonparametric statistics were used for analysis. Results: The results of the study included the following: (1) within the discordant twins group, the median chemerin concentration was significantly lower in the SGA group than in their cotwins; (2) within singletons, the median chemerin concentration was significantly higher in the LGA than the AGA newborns; and (3) the regression model revealed that chemerin was independently associated with birthweight. Conclusion: Cord blood chemerin is present in cord blood and its concentrations are positively correlated with birthweight. These novel findings support a role of adipokines in fetal growth.
KW - chemerin
KW - discordant twins
KW - fetal growth
KW - large for gestational age
KW - small for gestational age
UR - http://www.scopus.com/inward/record.url?scp=84868097876&partnerID=8YFLogxK
U2 - 10.1016/j.ajog.2012.08.008
DO - 10.1016/j.ajog.2012.08.008
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C2 - 22925375
AN - SCOPUS:84868097876
SN - 0002-9378
VL - 207
SP - 412.e1-412.e10
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 5
ER -