TY - JOUR
T1 - Chemerin concentrations in maternal and fetal compartments
T2 - Implications for metabolic adaptations to normal human pregnancy
AU - Kasher-Merona, Michal
AU - Mazaki-Tovia, Shali
AU - Barhod, Ehud
AU - Hemi, Rina
AU - Haas, Jigal
AU - Gat, Itai
AU - Zilberberg, Eran
AU - Yinon, Yoav
AU - Karasik, Avraham
AU - Kanety, Hannah
N1 - Funding Information:
Disclosure: All authors declare that there are no conflicts of interest. Funding: This study was supported by grants from the Mintz-Law Foundation of Tel-Aviv University and by the Talpiot Medical Leadership Program, Sheba Medical Center, Tel Hashomer, Israel.
PY - 2014/5
Y1 - 2014/5
N2 - Objectives: Chemerin, a novel adipocytokine, has been implicated in major metabolic and inflammatory processes. Study aims were to determine whether circulating maternal chemerin concentration (1) differs between pregnant and non-pregnant women, (2) changes as a function of gestational age, and (3) correlates with maternal insulin resistance. In addition, we investigated which compartment, maternal, fetal or placental, is the source of chemerin in maternal circulation. Methods: The study included three groups: Non-pregnant (n=18), pregnant women in the first trimester (n=19) and pregnant women in the third trimester (n = 33). Chemerin was measured in cord blood and in maternal serum samples taken before and after delivery. Chemerin mRNA expression was evaluated in fetal and human adult tissues. Results: Chemerin serum concentration was significantly higher in pregnant women in the third trimester than in non-pregnant and pregnant women in the first trimester. Chemerin concentration positively correlated with body mass index (BMI) and insulin resistance. Antenatal chemerin concentration was significantly lower than that during the postpartum period. Neonatal chemerin did not correlate with maternal one. Chemerin mRNA expression was abundant in fetal and adult liver and omental fat, but relatively low in placenta. Conclusions: Chemerin is increased during normal gestation and is associated with maternal BMI and insulin resistance. Maternal tissues, possibly liver and adipose tissue, contribute to the increased maternal chemerin concentration.
AB - Objectives: Chemerin, a novel adipocytokine, has been implicated in major metabolic and inflammatory processes. Study aims were to determine whether circulating maternal chemerin concentration (1) differs between pregnant and non-pregnant women, (2) changes as a function of gestational age, and (3) correlates with maternal insulin resistance. In addition, we investigated which compartment, maternal, fetal or placental, is the source of chemerin in maternal circulation. Methods: The study included three groups: Non-pregnant (n=18), pregnant women in the first trimester (n=19) and pregnant women in the third trimester (n = 33). Chemerin was measured in cord blood and in maternal serum samples taken before and after delivery. Chemerin mRNA expression was evaluated in fetal and human adult tissues. Results: Chemerin serum concentration was significantly higher in pregnant women in the third trimester than in non-pregnant and pregnant women in the first trimester. Chemerin concentration positively correlated with body mass index (BMI) and insulin resistance. Antenatal chemerin concentration was significantly lower than that during the postpartum period. Neonatal chemerin did not correlate with maternal one. Chemerin mRNA expression was abundant in fetal and adult liver and omental fat, but relatively low in placenta. Conclusions: Chemerin is increased during normal gestation and is associated with maternal BMI and insulin resistance. Maternal tissues, possibly liver and adipose tissue, contribute to the increased maternal chemerin concentration.
KW - Insulin resistance
KW - Metabolic syndrome
KW - Obesity
KW - Placenta.
UR - http://www.scopus.com/inward/record.url?scp=84904156708&partnerID=8YFLogxK
U2 - 10.1515/jpm-2013-0166
DO - 10.1515/jpm-2013-0166
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C2 - 24334424
AN - SCOPUS:84904156708
SN - 0300-5577
VL - 42
SP - 371
EP - 378
JO - Journal of Perinatal Medicine
JF - Journal of Perinatal Medicine
IS - 3
ER -