Characterization of plasma lipids and lipoproteins in patients with β2-glycoprotein I (Apolipoprotein H) deficiency

Jeffrey M. Hoeg, Pesach Segal*, Richard E. Gregg, Y. S. Chang, Frank T. Lindgren, Gerald L. Adamson, Michael Frank, Chaim Brickman, H. Bryan Brewer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The fasting plasma lipids, lipoproteins, and apolipoproteins were evaluated in 5 subjects with undetectable levels of the plasma protein β2-glycoprotein I (apolipoprotein H). Family studies confirmed an autosomal co-dominant inheritance pattern for the concentrations of apo H. The total lack of this protein is rare and less than 0.3% of clinic patients demonstrated levels undetectable by radial immunodiffusion. Plasma lipoprotein evaluation in these subjects with β2-glycoprotein I absence by analytical ultracentrifugation and compositional analysis demonstrated low concentrations of HDL2b and HDL3. More striking, however, was the lack of a consistent marked effect on the plasma lipoproteins as is found in other apolipoprotein deficiency states. We conclude that the lack of apolipoprotein H does not result in a significant perturbation of normal lipoprotein metabolism as reflected by analysis of fasting plasma lipoproteins. Further study is required to evaluate the role of this glycoprotein in the metabolism of triglyceride-rich lipoproteins.

Original languageEnglish
Pages (from-to)25-34
Number of pages10
JournalAtherosclerosis
Volume55
Issue number1
DOIs
StatePublished - Apr 1985
Externally publishedYes

Keywords

  • Apolipoprotein H
  • Apolipoproteins
  • Dyslipoproteinemia
  • Hyperlipoproteinemia
  • Lipoproteins
  • β-Glycoprotein I

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