@article{3d2911f99bd949ca97a1d587bc6e87cb,
title = "Characterization of IgM molecules in light-chain deficient variants of a B-cell tumor",
abstract = "Characterization of a membrane-IgM-negative variant cell line derived from the murine B-cell line 38C-13 revealed the absence of light chains and the presence of polypeptides with an apparent molecular size of 18 kDa and 14 kDa, previously denoted ω and i{dotless} and characteristic of pre-B cells. These polypeptides assemble with the μ chains into complexes with apparent molecular sizes of about 100 kDa and 200 kDa. It has been previously shown that light-chain-deficient variants of the 38C cell line undergo 'secondary' light chain rearrangements. It is suggested, therefore, that complexes of μ and the 'surrogate' light chains ω and i{dotless} play a role in this process. As these complexes do not reach the cell surface we would like to propose that the mechanism of secondary rearrangement is intracellularly controlled.",
keywords = "'Surrogate' light chain, IgM assembly, Pre B",
author = "Mahmoud Taya and Efrat Rabinovich and Joseph Haimovich",
note = "Funding Information: The studies reported in this paper have been supported in part by a research grant from the Israel Cancer Research Fund.",
year = "1992",
month = jul,
doi = "10.1016/0165-2478(92)90044-O",
language = "אנגלית",
volume = "33",
pages = "173--177",
journal = "Immunology Letters",
issn = "0165-2478",
publisher = "Elsevier B.V.",
number = "2",
}