Characterization of early plasma concentrations of midazolam in pigs after administration by an autoinjector

Aharon Levy, Moshe Kushnir, Shira Chapman, Rachel Brandeis, Zvi Teitelbaum, Eran Gilat

Research output: Contribution to journalArticlepeer-review


The treatment of organophosphate-induced poisoning is based mainly on atropine and an oxime. Prompt anticonvulsive intervention is usually also required to terminate the ensuing seizure activity and to prevent delayed permanent brain damage. Midazolam, a water-soluble benzodiazepine agonist, has the advantage of rapid absorption following intramuscular administration. In mass casualty situations, the availability of an autoinjector, filled with midazolam, might be a further advantage. In the present study, the plasma pharmacokinetics of midazolam after administration by an autoinjector was compared with conventional intramuscular (i.m.) administration in two groups of four pigs each. During the first 15 min after injection, significantly higher plasma concentrations of midazolam were detected following autoinjector administration, compared with the i.m. injection. The physiological reflection of the accelerated midazolam absorption was a marked reduction in the time interval required for muscle relaxation, induced by midazolam. It is concluded that a midazolam autoinjector might be helpful in the mass casualty scenario following organophosphate poisoning.

Original languageEnglish
Pages (from-to)297-301
Number of pages5
JournalBiopharmaceutics and Drug Disposition
Issue number7
StatePublished - Oct 2004
Externally publishedYes


  • Anticonvulsants
  • Benzodiazepines
  • Organophosphates
  • Sedation
  • Seizures


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