Characterization of a murine myeloma (MOPC-315) C-type virus by nucleic acid hybridization

Abraham Yaniv*, Arnona Gazit

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Employing DNA:RNA hybridization, the murine myeloma MOPC-315 C-type virus was found to be related to the murine leukemia-sarcoma group, sharing the highest degree of homology with AKR leukemia virus. DNA:DNA hybridization experiments with cellular DNAs of various animal species revealed that MOPC-315 viral genome is related extensively to mouse DNA, pointing to the mouse as its species of origin. MOPC-315 viral transcript showed identical Cot 1 2 values, final extents of hybridization, as well as Tm values when hybridized either to MOPC-315 cellular DNA or to normal BALB/c DNA, thus indicating that the investigated particle is an endogenous virus of the mouse.

Original languageEnglish
Pages (from-to)256-259
Number of pages4
Issue number1
StatePublished - Feb 1979


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