Characteristics of very poor outcome schizophrenia

R. S.E. Keefe, R. C. Mohs, M. F. Losonczy, M. Davidson, J. M. Silverman, K. S. Kendler, T. B. Horvath, R. Nora, K. L. Davis

Research output: Contribution to journalArticlepeer-review

183 Scopus citations

Abstract

The authors compared 21 'Kraepelinian' schizophrenic patients who had been ill and dependent on others for the past 5 years with 76 chronic schizophrenic patients in remission or with exacerbations requiring hospitalization. The Kraepelinian patients met the criteria for schizophrenia by more diagnostic systems than the exacerbated patients, were less responsive to haloperidol, had more severe negative symptoms, and had similarly severe positive symptoms. They had cerebral ventricles that were more asymmetrical and a greater family history of schizophrenia spectrum disorders than the other chronic patients. These data suggest that patients with 5 years of illness and complete dependency on others may represent a subgroup of schizophrenia.

Original languageEnglish
Pages (from-to)889-895
Number of pages7
JournalAmerican Journal of Psychiatry
Volume144
Issue number7
DOIs
StatePublished - 1987

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