Characteristics of SCCmec IV and V methicillin-resistant Staphylococcus aureus (MRSA) in Israel

Pnina Shitrit, Michal Openhaim, Sharon Reisfeld, Yossi Paitan, Gili Regev-Yochay, Yehuda Carmeli, Michal Chowers

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Isolation of methicillin-resistant Staphylococcus aureus (MRSA) in healthy individuals is not common in Israel. In our hospital, about 30% of MRSA isolates were SCCmec types IV and V. Objectives: To identify the demographic and clinical characteristics of patients carrying MRSA SCCmec type IV or V, and to compare them with each other and with those of patients with SCCmec types I-III. Methods: We conducted a case-control study that included 501 patients from whom MRSA was isolated: 254 with SCCmec type I, II, or III, and 243 isolates from SCCmec types IV or V. Results: MRSA was isolated from surveillance cultures in 75% of patients and from a clinical site in 25%. The majority of our study population was elderly, from nursing homes, and with extensive exposure to health care. First, we compared characteristics of patients identified through screening. Statistically significant predictors of SCCmec V vs. IV were Arab ethnicity (OR 7.44, 95%CI 1.5–37.9) and hospitalization in the year prior to study inclusion (OR 5.7, 95%CI 1.9–16.9). No differences were found between patients with SCCmec types I-III and patients with SCCmec type IV or V. Analysis of the subset of patients who had clinical cultures yielded similar results. Conclusions: SCCmec types IV and V were common in the hospital setting although rare in the community. It seems that in Israel, SCCmec IV and V are predominantly health careassociated MRSA.

Original languageEnglish
Pages (from-to)470-475
Number of pages6
JournalIsrael Medical Association Journal
Volume17
Issue number8
StatePublished - 1 Aug 2015

Keywords

  • Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA)
  • Hospital-acquired methicillin-resistant Staphylococcus aureus (HA-MRSA)
  • SCCmec IV
  • SCCmec V

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