CHARACTERISTICS OF PIGMENTED LESIONS IN TYPE 2 IDIOPATHIC MACULAR TELANGIECTASIA

Irene Leung; Ferenc B. Sallo; Roberto Bonelli; Traci E. Clemons; Daniel Pauleikhoff; Emily Y. Chew; Alan C. Bird; Tunde Peto; Jose Alain Sahel; Robyn Guymer; Gisele Soubrane; Alain Gaudric; Steven Schwartz; Ian Constable; Michael Cooney; Catherine Egan; Lawrence Singerman; Mark C. Gillies; Martin Friedlander; Daniel Pauleikhoff; Joseph Moisseiev; Richard Rosen; Robert Murphy; Frank Holz; Grant Comer; Barbara Blodi; Diana Do; Alexander Brucker; Raja Narayanan; Sebastian Wolf; Philip Rosenfeld; Paul S. Bernstein; Lawrence Yannuzzi; Jacque Duncan; Mina Chung; Jiong Yan; David Weinberg; Clasien Oomen; Joan W. Miller

doi:10.1097/IAE.0000000000001842

CHARACTERISTICS OF PIGMENTED LESIONS IN TYPE 2 IDIOPATHIC MACULAR TELANGIECTASIA

Irene Leung, Ferenc B. Sallo^*, Roberto Bonelli, Traci E. Clemons, Daniel Pauleikhoff, Emily Y. Chew, Alan C. Bird, Tunde Peto, Jose Alain Sahel, Robyn Guymer, Gisele Soubrane, Alain Gaudric, Steven Schwartz, Ian Constable, Michael Cooney, Catherine Egan, Lawrence Singerman, Mark C. Gillies, Martin Friedlander, Daniel PauleikhoffJoseph Moisseiev, Richard Rosen, Robert Murphy, Frank Holz, Grant Comer, Barbara Blodi, Diana Do, Alexander Brucker, Raja Narayanan, Sebastian Wolf, Philip Rosenfeld, Paul S. Bernstein, Lawrence Yannuzzi, Jacque Duncan, Mina Chung, Jiong Yan, David Weinberg, Clasien Oomen, Joan W. Miller

^*Corresponding author for this work

Clinical Departments

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: Pigment in the midretina is a characteristic sign in Type 2 idiopathic macular telangiectasia (MacTel) and is considered to characterize the late stage of the disease. Our aim was to investigate its incidence, and relationship with risk factors for MacTel, including outer retinal vascularization and subretinal neovascular proliferation (SRNV). Methods: Pigment extent was measured in fundus autofluorescence images of 150 eyes of 75 MacTel probands, using the Region Finder tool of Heidelberg Eye Explorer. A linear mixed model was used to analyze the dynamics of pigment and its associations with other features of the phenotype. The relative incidence of pigment and of outer retinal outer retinal vascularization and SRNV was analyzed within the full MacTel Study cohort (1,244 probands). Results: Mean pigment area at baseline was 0.157 mm² (range = 0–1.295 mm², SD = 0.228 mm², n = 101). Progression demonstrated a nonlinear pattern (P, 0.001) at an overall rate of 0.0177 mm²/year and was associated with the initial plaque size and with SRNV. There was a strong correlation between fellow eyes (P # 0.0001). In approximately 25% of all SRNV cases, SRNV may coincide with or precede pigment. Conclusion: Our data may be useful for refining the current system for staging disease severity in MacTel.

Original language	English
Pages (from-to)	S43-S50
Journal	Retina
Volume	38
DOIs	https://doi.org/10.1097/IAE.0000000000001842
State	Published - 1 Jan 2018

Keywords

Degeneration
Imaging
MacTel
Müller cells
OCT
Pigment
Retina
Telangiectasia

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Leung, I., Sallo, F. B., Bonelli, R., Clemons, T. E., Pauleikhoff, D., Chew, E. Y., Bird, A. C., Peto, T., Sahel, J. A., Guymer, R., Soubrane, G., Gaudric, A., Schwartz, S., Constable, I., Cooney, M., Egan, C., Singerman, L., Gillies, M. C., Friedlander, M., ... Miller, J. W. (2018). CHARACTERISTICS OF PIGMENTED LESIONS IN TYPE 2 IDIOPATHIC MACULAR TELANGIECTASIA. Retina, 38, S43-S50. https://doi.org/10.1097/IAE.0000000000001842

@article{464f4314311a4d58b9413d16875a8a08,

title = "CHARACTERISTICS OF PIGMENTED LESIONS IN TYPE 2 IDIOPATHIC MACULAR TELANGIECTASIA",

abstract = "Purpose: Pigment in the midretina is a characteristic sign in Type 2 idiopathic macular telangiectasia (MacTel) and is considered to characterize the late stage of the disease. Our aim was to investigate its incidence, and relationship with risk factors for MacTel, including outer retinal vascularization and subretinal neovascular proliferation (SRNV). Methods: Pigment extent was measured in fundus autofluorescence images of 150 eyes of 75 MacTel probands, using the Region Finder tool of Heidelberg Eye Explorer. A linear mixed model was used to analyze the dynamics of pigment and its associations with other features of the phenotype. The relative incidence of pigment and of outer retinal outer retinal vascularization and SRNV was analyzed within the full MacTel Study cohort (1,244 probands). Results: Mean pigment area at baseline was 0.157 mm2 (range = 0–1.295 mm2, SD = 0.228 mm2, n = 101). Progression demonstrated a nonlinear pattern (P, 0.001) at an overall rate of 0.0177 mm2/year and was associated with the initial plaque size and with SRNV. There was a strong correlation between fellow eyes (P # 0.0001). In approximately 25% of all SRNV cases, SRNV may coincide with or precede pigment. Conclusion: Our data may be useful for refining the current system for staging disease severity in MacTel.",

keywords = "Degeneration, Imaging, MacTel, M{\"u}ller cells, OCT, Pigment, Retina, Telangiectasia",

author = "Irene Leung and Sallo, {Ferenc B.} and Roberto Bonelli and Clemons, {Traci E.} and Daniel Pauleikhoff and Chew, {Emily Y.} and Bird, {Alan C.} and Tunde Peto and Sahel, {Jose Alain} and Robyn Guymer and Gisele Soubrane and Alain Gaudric and Steven Schwartz and Ian Constable and Michael Cooney and Catherine Egan and Lawrence Singerman and Gillies, {Mark C.} and Martin Friedlander and Daniel Pauleikhoff and Joseph Moisseiev and Richard Rosen and Robert Murphy and Frank Holz and Grant Comer and Barbara Blodi and Diana Do and Alexander Brucker and Raja Narayanan and Sebastian Wolf and Philip Rosenfeld and Bernstein, {Paul S.} and Lawrence Yannuzzi and Jacque Duncan and Mina Chung and Jiong Yan and David Weinberg and Clasien Oomen and Miller, {Joan W.}",

year = "2018",

month = jan,

day = "1",

doi = "10.1097/IAE.0000000000001842",

language = "אנגלית",

volume = "38",

pages = "S43--S50",

journal = "Retina",

issn = "0275-004X",

publisher = "Lippincott Williams and Wilkins Ltd.",

}

Leung, I, Sallo, FB, Bonelli, R, Clemons, TE, Pauleikhoff, D, Chew, EY, Bird, AC, Peto, T, Sahel, JA, Guymer, R, Soubrane, G, Gaudric, A, Schwartz, S, Constable, I, Cooney, M, Egan, C, Singerman, L, Gillies, MC, Friedlander, M, Pauleikhoff, D, Moisseiev, J, Rosen, R, Murphy, R, Holz, F, Comer, G, Blodi, B, Do, D, Brucker, A, Narayanan, R, Wolf, S, Rosenfeld, P, Bernstein, PS, Yannuzzi, L, Duncan, J, Chung, M, Yan, J, Weinberg, D, Oomen, C & Miller, JW 2018, 'CHARACTERISTICS OF PIGMENTED LESIONS IN TYPE 2 IDIOPATHIC MACULAR TELANGIECTASIA', Retina, vol. 38, pp. S43-S50. https://doi.org/10.1097/IAE.0000000000001842

TY - JOUR

T1 - CHARACTERISTICS OF PIGMENTED LESIONS IN TYPE 2 IDIOPATHIC MACULAR TELANGIECTASIA

AU - Leung, Irene

AU - Sallo, Ferenc B.

AU - Bonelli, Roberto

AU - Clemons, Traci E.

AU - Pauleikhoff, Daniel

AU - Chew, Emily Y.

AU - Bird, Alan C.

AU - Peto, Tunde

AU - Sahel, Jose Alain

AU - Guymer, Robyn

AU - Soubrane, Gisele

AU - Gaudric, Alain

AU - Schwartz, Steven

AU - Constable, Ian

AU - Cooney, Michael

AU - Egan, Catherine

AU - Singerman, Lawrence

AU - Gillies, Mark C.

AU - Friedlander, Martin

AU - Pauleikhoff, Daniel

AU - Moisseiev, Joseph

AU - Rosen, Richard

AU - Murphy, Robert

AU - Holz, Frank

AU - Comer, Grant

AU - Blodi, Barbara

AU - Do, Diana

AU - Brucker, Alexander

AU - Narayanan, Raja

AU - Wolf, Sebastian

AU - Rosenfeld, Philip

AU - Bernstein, Paul S.

AU - Yannuzzi, Lawrence

AU - Duncan, Jacque

AU - Chung, Mina

AU - Yan, Jiong

AU - Weinberg, David

AU - Oomen, Clasien

AU - Miller, Joan W.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Purpose: Pigment in the midretina is a characteristic sign in Type 2 idiopathic macular telangiectasia (MacTel) and is considered to characterize the late stage of the disease. Our aim was to investigate its incidence, and relationship with risk factors for MacTel, including outer retinal vascularization and subretinal neovascular proliferation (SRNV). Methods: Pigment extent was measured in fundus autofluorescence images of 150 eyes of 75 MacTel probands, using the Region Finder tool of Heidelberg Eye Explorer. A linear mixed model was used to analyze the dynamics of pigment and its associations with other features of the phenotype. The relative incidence of pigment and of outer retinal outer retinal vascularization and SRNV was analyzed within the full MacTel Study cohort (1,244 probands). Results: Mean pigment area at baseline was 0.157 mm2 (range = 0–1.295 mm2, SD = 0.228 mm2, n = 101). Progression demonstrated a nonlinear pattern (P, 0.001) at an overall rate of 0.0177 mm2/year and was associated with the initial plaque size and with SRNV. There was a strong correlation between fellow eyes (P # 0.0001). In approximately 25% of all SRNV cases, SRNV may coincide with or precede pigment. Conclusion: Our data may be useful for refining the current system for staging disease severity in MacTel.

AB - Purpose: Pigment in the midretina is a characteristic sign in Type 2 idiopathic macular telangiectasia (MacTel) and is considered to characterize the late stage of the disease. Our aim was to investigate its incidence, and relationship with risk factors for MacTel, including outer retinal vascularization and subretinal neovascular proliferation (SRNV). Methods: Pigment extent was measured in fundus autofluorescence images of 150 eyes of 75 MacTel probands, using the Region Finder tool of Heidelberg Eye Explorer. A linear mixed model was used to analyze the dynamics of pigment and its associations with other features of the phenotype. The relative incidence of pigment and of outer retinal outer retinal vascularization and SRNV was analyzed within the full MacTel Study cohort (1,244 probands). Results: Mean pigment area at baseline was 0.157 mm2 (range = 0–1.295 mm2, SD = 0.228 mm2, n = 101). Progression demonstrated a nonlinear pattern (P, 0.001) at an overall rate of 0.0177 mm2/year and was associated with the initial plaque size and with SRNV. There was a strong correlation between fellow eyes (P # 0.0001). In approximately 25% of all SRNV cases, SRNV may coincide with or precede pigment. Conclusion: Our data may be useful for refining the current system for staging disease severity in MacTel.

KW - Degeneration

KW - Imaging

KW - MacTel

KW - Müller cells

KW - OCT

KW - Pigment

KW - Retina

KW - Telangiectasia

UR - http://www.scopus.com/inward/record.url?scp=85042614696&partnerID=8YFLogxK

U2 - 10.1097/IAE.0000000000001842

DO - 10.1097/IAE.0000000000001842

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 29095354

AN - SCOPUS:85042614696

SN - 0275-004X

VL - 38

SP - S43-S50

JO - Retina

JF - Retina

ER -

CHARACTERISTICS OF PIGMENTED LESIONS IN TYPE 2 IDIOPATHIC MACULAR TELANGIECTASIA

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Keywords

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