TY - JOUR
T1 - Characteristics and risk factors of infections following CD28-based CD19 CAR-T cells
AU - Wittmann Dayagi, Talya
AU - Sherman, Gilad
AU - Bielorai, Bella
AU - Adam, Etai
AU - Besser, Michal J.
AU - Shimoni, Avichai
AU - Nagler, Arnon
AU - Toren, Amos
AU - Jacoby, Elad
AU - Avigdor, Abraham
N1 - Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - CAR T-cells are approved for the treatment of relapsed and refractory leukemia and lymphoma. Here, we studied the infectious complications in 88 patients treated with CD28-based CD19 CAR T-cells. Overall, 36 infections were documented in 24 patients within the first month after CAR T-cell infusion: Six events of bacteremia, sixteen focal bacterial infections, and fourteen systemic or localized viral infections. Seven patients had nine infectious episodes beyond the first 30 days of follow-up, including three events of bacteremia, three focal bacterial, two viral and one fungal infection. The presence of neutropenia, neutropenic fever and lack of response to treatment were associated with a higher rate of infections. Children had less severe infections than adults. In a multivariate analysis lack of response to treatment was the only significant risk factor. Overall, the incidence of bacterial infections following CAR T-cells is modest especially in children and in patients responding to therapy.
AB - CAR T-cells are approved for the treatment of relapsed and refractory leukemia and lymphoma. Here, we studied the infectious complications in 88 patients treated with CD28-based CD19 CAR T-cells. Overall, 36 infections were documented in 24 patients within the first month after CAR T-cell infusion: Six events of bacteremia, sixteen focal bacterial infections, and fourteen systemic or localized viral infections. Seven patients had nine infectious episodes beyond the first 30 days of follow-up, including three events of bacteremia, three focal bacterial, two viral and one fungal infection. The presence of neutropenia, neutropenic fever and lack of response to treatment were associated with a higher rate of infections. Children had less severe infections than adults. In a multivariate analysis lack of response to treatment was the only significant risk factor. Overall, the incidence of bacterial infections following CAR T-cells is modest especially in children and in patients responding to therapy.
KW - CAR T-cells
KW - cytokine-release syndrome
KW - infections
KW - leukemia
KW - lymphoma
UR - http://www.scopus.com/inward/record.url?scp=85101171056&partnerID=8YFLogxK
U2 - 10.1080/10428194.2021.1881506
DO - 10.1080/10428194.2021.1881506
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C2 - 33563059
AN - SCOPUS:85101171056
SN - 1042-8194
VL - 62
SP - 1692
EP - 1701
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 7
ER -
