Characteristics and outcome of multiple myeloma patients presenting with anaemia only: A retrospective multi-centre study

Tamir Shragai; Moshe E. Gatt; Adir Shaulov; Eirini Katodritou; Theodora Triantafyllou; Noa Lavi; Anastasia Pouli; Anastasia Sioni; Iuliana Vaxman; Miri Zektser; Chezi Ganzel; Noam Benyamini; Svetlana Trestman; Tomer Ziv-Baran; Yasmin Adam; Yael C. Cohen; Irit Avivi

doi:10.1016/j.leukres.2020.106498

Characteristics and outcome of multiple myeloma patients presenting with anaemia only: A retrospective multi-centre study

Tamir Shragai^*, Moshe E. Gatt, Adir Shaulov, Eirini Katodritou, Theodora Triantafyllou, Noa Lavi, Anastasia Pouli, Anastasia Sioni, Iuliana Vaxman, Miri Zektser, Chezi Ganzel, Noam Benyamini, Svetlana Trestman, Tomer Ziv-Baran, Yasmin Adam, Yael C. Cohen, Irit Avivi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: Multiple myeloma (MM) patients presenting with anaemia as their sole clinical manifestation are rare and not fully defined. Methods: Retrospective multi-site study comparing the characteristics and outcome of MM patients with anaemia only with matched patients, presenting with multi-organ disease. Results: Anaemia-only patients had a higher percentage of bone marrow monoclonal plasma cells group (median 60% [IQR 42−80%] vs. 37% [IQR 17–65%], respectively; p < 0.001), and a lower responsiveness to treatment (≥VGPR rates were 54% vs 74%, p = 0.049). Median survival in anaemia only patients was 65.9 ± 6.9 vs 83.4 ± 8.8 months in matched control patients (P = n.s). Conclusions: MM patients presenting with anaemia only represents a unique, potentially less favorable population.

Original language	English
Article number	106498
Journal	Leukemia Research
Volume	101
DOIs	https://doi.org/10.1016/j.leukres.2020.106498
State	Published - Feb 2021

Keywords

Anemia
Myeloma

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10.1016/j.leukres.2020.106498

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Shragai, T., Gatt, M. E., Shaulov, A., Katodritou, E., Triantafyllou, T., Lavi, N., Pouli, A., Sioni, A., Vaxman, I., Zektser, M., Ganzel, C., Benyamini, N., Trestman, S., Ziv-Baran, T., Adam, Y., Cohen, Y. C., & Avivi, I. (2021). Characteristics and outcome of multiple myeloma patients presenting with anaemia only: A retrospective multi-centre study. Leukemia Research, 101, Article 106498. https://doi.org/10.1016/j.leukres.2020.106498

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title = "Characteristics and outcome of multiple myeloma patients presenting with anaemia only: A retrospective multi-centre study",

abstract = "Background: Multiple myeloma (MM) patients presenting with anaemia as their sole clinical manifestation are rare and not fully defined. Methods: Retrospective multi-site study comparing the characteristics and outcome of MM patients with anaemia only with matched patients, presenting with multi-organ disease. Results: Anaemia-only patients had a higher percentage of bone marrow monoclonal plasma cells group (median 60% [IQR 42−80%] vs. 37% [IQR 17–65%], respectively; p < 0.001), and a lower responsiveness to treatment (≥VGPR rates were 54% vs 74%, p = 0.049). Median survival in anaemia only patients was 65.9 ± 6.9 vs 83.4 ± 8.8 months in matched control patients (P = n.s). Conclusions: MM patients presenting with anaemia only represents a unique, potentially less favorable population.",

keywords = "Anemia, Myeloma",

author = "Tamir Shragai and Gatt, {Moshe E.} and Adir Shaulov and Eirini Katodritou and Theodora Triantafyllou and Noa Lavi and Anastasia Pouli and Anastasia Sioni and Iuliana Vaxman and Miri Zektser and Chezi Ganzel and Noam Benyamini and Svetlana Trestman and Tomer Ziv-Baran and Yasmin Adam and Cohen, {Yael C.} and Irit Avivi",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2021",

month = feb,

doi = "10.1016/j.leukres.2020.106498",

language = "אנגלית",

volume = "101",

journal = "Leukemia Research",

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Shragai, T, Gatt, ME, Shaulov, A, Katodritou, E, Triantafyllou, T, Lavi, N, Pouli, A, Sioni, A, Vaxman, I, Zektser, M, Ganzel, C, Benyamini, N, Trestman, S, Ziv-Baran, T, Adam, Y, Cohen, YC & Avivi, I 2021, 'Characteristics and outcome of multiple myeloma patients presenting with anaemia only: A retrospective multi-centre study', Leukemia Research, vol. 101, 106498. https://doi.org/10.1016/j.leukres.2020.106498

TY - JOUR

T1 - Characteristics and outcome of multiple myeloma patients presenting with anaemia only

T2 - A retrospective multi-centre study

AU - Shragai, Tamir

AU - Gatt, Moshe E.

AU - Shaulov, Adir

AU - Katodritou, Eirini

AU - Triantafyllou, Theodora

AU - Lavi, Noa

AU - Pouli, Anastasia

AU - Sioni, Anastasia

AU - Vaxman, Iuliana

AU - Zektser, Miri

AU - Ganzel, Chezi

AU - Benyamini, Noam

AU - Trestman, Svetlana

AU - Ziv-Baran, Tomer

AU - Adam, Yasmin

AU - Cohen, Yael C.

AU - Avivi, Irit

PY - 2021/2

Y1 - 2021/2

N2 - Background: Multiple myeloma (MM) patients presenting with anaemia as their sole clinical manifestation are rare and not fully defined. Methods: Retrospective multi-site study comparing the characteristics and outcome of MM patients with anaemia only with matched patients, presenting with multi-organ disease. Results: Anaemia-only patients had a higher percentage of bone marrow monoclonal plasma cells group (median 60% [IQR 42−80%] vs. 37% [IQR 17–65%], respectively; p < 0.001), and a lower responsiveness to treatment (≥VGPR rates were 54% vs 74%, p = 0.049). Median survival in anaemia only patients was 65.9 ± 6.9 vs 83.4 ± 8.8 months in matched control patients (P = n.s). Conclusions: MM patients presenting with anaemia only represents a unique, potentially less favorable population.

AB - Background: Multiple myeloma (MM) patients presenting with anaemia as their sole clinical manifestation are rare and not fully defined. Methods: Retrospective multi-site study comparing the characteristics and outcome of MM patients with anaemia only with matched patients, presenting with multi-organ disease. Results: Anaemia-only patients had a higher percentage of bone marrow monoclonal plasma cells group (median 60% [IQR 42−80%] vs. 37% [IQR 17–65%], respectively; p < 0.001), and a lower responsiveness to treatment (≥VGPR rates were 54% vs 74%, p = 0.049). Median survival in anaemia only patients was 65.9 ± 6.9 vs 83.4 ± 8.8 months in matched control patients (P = n.s). Conclusions: MM patients presenting with anaemia only represents a unique, potentially less favorable population.

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KW - Myeloma

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Characteristics and outcome of multiple myeloma patients presenting with anaemia only: A retrospective multi-centre study

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