Changes over time in patient-reported outcomes in patients with heart failure

Tiny Jaarsma*, Naoko P. Kato, Leonie Klompstra, Tuvia Ben Gal, Josiane Boyne, Eva Hägglund, Ercole Vellone, Andreas Hagenow, Lorraine S. Evangelista, Jan Mårtensson, Anna Strömberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Aim: This paper describes the trajectory during 1 year of four patient-reported outcomes (PROs), namely, sleep, depressive symptoms, health-related quality of life (HrQoL), and well-being, in patients with heart failure (HF), their relationship and the patient characteristics associated with changes in these PROs. Methods and results: Data analyses of PROs from 603 patients (mean age 67 years; 29% female, 60% NYHA II) enrolled in the HF-Wii study. On short term, between baseline and 3 months, 16% of the patients experienced continuing poor sleep, 11% had sustained depressive symptoms, 13% had consistent poor HrQoL, and 13% consistent poor well-being. Across the entire 1-year period only 21% of the patients had good PRO scores at all timepoints (baseline, 3, 6, and 12 months). All others had at least one low score in any of the PROs at some timepoint during the study. Over the 12 months, 17% had consistently poor sleep, 17% had sustained symptoms of depression, 15% consistently rated a poor HrQoL, and 13% poor well-being. Different patient characteristics per PRO were associated with a poor outcomes across the 12 months. Age, education, New York Heart Association, and length of disease were related to two PRO domains and submaximal exercise capacity (6 min test), co-morbidity, and poor physical activity to one. Conclusion: In total, 79% of the patients with HF encountered problems related to sleep, depressive symptoms, HrQoL, and well-being at least once during a 1-year period. This underscores the need for continuous monitoring and follow-up of patients with HF and the need for dynamic adjustments in treatment and care regularly throughout the HF trajectory.

Original languageEnglish
Pages (from-to)811-818
Number of pages8
JournalESC heart failure
Issue number2
StatePublished - Apr 2024


FundersFunder number
Swedish National Science CouncilK2013‐69X‐22302‐01‐3, 2016‐01390
Swedish National Science Council/Swedish Research Council for Health, Working Life and Welfare2014‐4100
Forskningsrådet i Sydöstra Sverige474681
Riksförbundet HjärtLungE085/12
Hjärt-Lungfonden20130340, 20160439


    • Heart failure
    • Patient-reported outcomes
    • Quality of life
    • Symptoms


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