Changes of cell shape and surface charge topography in ATP-depleted human red blood cells

Yehuda Marikovsky; Ronald S. Weinstein; Ehud Skutelsky; David Danon

doi:10.1016/0047-6374(85)90070-3

Changes of cell shape and surface charge topography in ATP-depleted human red blood cells

Yehuda Marikovsky^*, Ronald S. Weinstein, Ehud Skutelsky, David Danon

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

ATP depletion crenates human red blood cells. With ferritin-avidin (FA) and cationized ferritin (CF) cell surface labeling, it is demonstrated that the discocyte → crenated shape transformation alters the two-dimensional topography of negative charge sites. With restoration of ATP levels, cell shape and charge topography return to normal. Concurrent changes in red cell shape and surface charge topography can be explained by associations between membrane integral proteins and the red cell cytoskeleton.

Original language	English
Pages (from-to)	309-316
Number of pages	8
Journal	Mechanisms of Ageing and Development
Volume	29
Issue number	3
DOIs	https://doi.org/10.1016/0047-6374(85)90070-3
State	Published - Mar 1985

Keywords

ATP-depletion
Cell shape
Erythrocyte
Surface charge

Access to Document

10.1016/0047-6374(85)90070-3

Cite this

@article{76ab6482092c4c4b8842fd9bd21942a6,

title = "Changes of cell shape and surface charge topography in ATP-depleted human red blood cells",

abstract = "ATP depletion crenates human red blood cells. With ferritin-avidin (FA) and cationized ferritin (CF) cell surface labeling, it is demonstrated that the discocyte → crenated shape transformation alters the two-dimensional topography of negative charge sites. With restoration of ATP levels, cell shape and charge topography return to normal. Concurrent changes in red cell shape and surface charge topography can be explained by associations between membrane integral proteins and the red cell cytoskeleton.",

keywords = "ATP-depletion, Cell shape, Erythrocyte, Surface charge",

author = "Yehuda Marikovsky and Weinstein, {Ronald S.} and Ehud Skutelsky and David Danon",

year = "1985",

month = mar,

doi = "10.1016/0047-6374(85)90070-3",

language = "אנגלית",

volume = "29",

pages = "309--316",

journal = "Mechanisms of Ageing and Development",

issn = "0047-6374",

publisher = "Elsevier Ireland Ltd",

number = "3",

}

TY - JOUR

T1 - Changes of cell shape and surface charge topography in ATP-depleted human red blood cells

AU - Marikovsky, Yehuda

AU - Weinstein, Ronald S.

AU - Skutelsky, Ehud

AU - Danon, David

PY - 1985/3

Y1 - 1985/3

N2 - ATP depletion crenates human red blood cells. With ferritin-avidin (FA) and cationized ferritin (CF) cell surface labeling, it is demonstrated that the discocyte → crenated shape transformation alters the two-dimensional topography of negative charge sites. With restoration of ATP levels, cell shape and charge topography return to normal. Concurrent changes in red cell shape and surface charge topography can be explained by associations between membrane integral proteins and the red cell cytoskeleton.

AB - ATP depletion crenates human red blood cells. With ferritin-avidin (FA) and cationized ferritin (CF) cell surface labeling, it is demonstrated that the discocyte → crenated shape transformation alters the two-dimensional topography of negative charge sites. With restoration of ATP levels, cell shape and charge topography return to normal. Concurrent changes in red cell shape and surface charge topography can be explained by associations between membrane integral proteins and the red cell cytoskeleton.

KW - ATP-depletion

KW - Cell shape

KW - Erythrocyte

KW - Surface charge

UR - http://www.scopus.com/inward/record.url?scp=0021867393&partnerID=8YFLogxK

U2 - 10.1016/0047-6374(85)90070-3

DO - 10.1016/0047-6374(85)90070-3

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:0021867393

SN - 0047-6374

VL - 29

SP - 309

EP - 316

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

IS - 3

ER -

Changes of cell shape and surface charge topography in ATP-depleted human red blood cells

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this