TY - JOUR
T1 - Changes observed in slow-growing melanomas during long-term dermoscopic monitoring
AU - Terushkin, V.
AU - Dusza, S. W.
AU - Scope, A.
AU - Argenziano, G.
AU - Bahadoran, P.
AU - Cowell, L.
AU - De Giorgi, V.
AU - Ferrara, G.
AU - Kittler, H.
AU - Malvehy, J.
AU - Menzies, S.
AU - Piccolo, D.
AU - Puig, S.
AU - Rubegni, P.
AU - Stanganelli, I.
AU - Thomas, L.
AU - Zalaudek, I.
AU - Marghoob, A. A.
PY - 2012/6
Y1 - 2012/6
N2 - Background: Melanomas vary in growth rate from rapidly developing nodular melanomas to slow-growing melanomas (SGM) that hardly change over years. Objectives: To evaluate longitudinal changes in dermoscopic findings of SGM. Methods We retrospectively analysed a dermoscopic image dataset from 15 pigmented lesion clinics, of SGM that were followed sequentially by digital dermoscopy for at least 1 year. We evaluated baseline and follow-up images for changes in global pattern, organization, colours, structure and size. Results: Our series consisted of 92 SGM. On follow-up, these melanomas developed the following dermoscopic findings: more homogeneous and less reticular global dermoscopic pattern; more frequent disorganization of pattern (baseline, 67% vs. follow-up, 79%); decreased prominence of light brown colour, increased prominence of dark brown colour, and increased frequency of the colours red, white, grey, blue and black (baseline: 29%, 3%, 18%, 6% and 33% vs. follow-up: 41%, 10%, 31%, 13% and 45%, respectively); decrease in prominence of dermoscopic structure of pigmented network, with a concomitant increase in prominence of structureless areas; and increased prominence or new appearance of melanoma-specific dermoscopic structures, including negative network, blue-white structures and blotches. The majority of lesions (75%) remained the same size or grew by < 2 mm in diameter. An increase in lesion size was associated with change in the total number of colours and structures (χ 2 = 14·3, P = 0·027) at follow-up. Conclusions: While their diameter changed minimally over time, most SGM became more disorganized, revealed loss of network in favour of structureless areas, and developed new colours.
AB - Background: Melanomas vary in growth rate from rapidly developing nodular melanomas to slow-growing melanomas (SGM) that hardly change over years. Objectives: To evaluate longitudinal changes in dermoscopic findings of SGM. Methods We retrospectively analysed a dermoscopic image dataset from 15 pigmented lesion clinics, of SGM that were followed sequentially by digital dermoscopy for at least 1 year. We evaluated baseline and follow-up images for changes in global pattern, organization, colours, structure and size. Results: Our series consisted of 92 SGM. On follow-up, these melanomas developed the following dermoscopic findings: more homogeneous and less reticular global dermoscopic pattern; more frequent disorganization of pattern (baseline, 67% vs. follow-up, 79%); decreased prominence of light brown colour, increased prominence of dark brown colour, and increased frequency of the colours red, white, grey, blue and black (baseline: 29%, 3%, 18%, 6% and 33% vs. follow-up: 41%, 10%, 31%, 13% and 45%, respectively); decrease in prominence of dermoscopic structure of pigmented network, with a concomitant increase in prominence of structureless areas; and increased prominence or new appearance of melanoma-specific dermoscopic structures, including negative network, blue-white structures and blotches. The majority of lesions (75%) remained the same size or grew by < 2 mm in diameter. An increase in lesion size was associated with change in the total number of colours and structures (χ 2 = 14·3, P = 0·027) at follow-up. Conclusions: While their diameter changed minimally over time, most SGM became more disorganized, revealed loss of network in favour of structureless areas, and developed new colours.
UR - http://www.scopus.com/inward/record.url?scp=84861618606&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2133.2012.10846.x
DO - 10.1111/j.1365-2133.2012.10846.x
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 22283805
AN - SCOPUS:84861618606
SN - 0007-0963
VL - 166
SP - 1213
EP - 1220
JO - British Journal of Dermatology
JF - British Journal of Dermatology
IS - 6
ER -