Changes in the effects of interleukin-1β and tumor necrosis factor-α on platelet activation in early pregnancy

J. Bar, A. Zosmer, M. Hod, J. Lahav, M. G. Elder, M. H.F. Sullivan

Research output: Contribution to journalArticlepeer-review

Abstract

Platelets are known to be activated in normal pregnancy, and are further activated in pathological pregnancy states, such as preeclampsia. The factors controlling platelet activation are unknown, but cytokines, such as interleukin 1β (IL-1β) and tumor necrosis-α (TNF-α) have been found to affect platelet function and are believed to be involved in early pregnancy. We assessed the effects of these cytokines on platelets from women at various stages of pregnancy. We compared two methods: platelet in vitro aggregation by aggregometry, and platelet P-selectin expression by flow cytometry. IL-1β and TNF-α had no effect on the in vitro aggregation and P-selectin expression of platelets from women in the first trimester of pregnancy as compared to the inhibitory effects of both in late pregnancy. We conclude that maternal platelet function undergoes a marked change throughout pregnancy.

Original languageEnglish
Pages (from-to)453-455
Number of pages3
JournalPlatelets
Volume12
Issue number8
DOIs
StatePublished - 2001

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