Changes in the dynamic network structure of PTSD symptoms pre-to-post combat

Adva Segal*, Ilan Wald, Gad Lubin, Eyal Fruchter, Keren Ginat, Ariel Ben Yehuda, Daniel S. Pine, Yair Bar-Haim

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Background Combat exposure is associated with elevated risk for post-traumatic stress disorder (PTSD). Despite considerable research on PTSD symptom clustering, it remains unknown how symptoms of PTSD re-organize following combat. Network analysis provides a powerful tool to examine such changes.Methods A network analysis approach was taken to examine how symptom networks change from pre- to post-combat using longitudinal prospective data from a cohort of infantry male soldiers (Mage = 18.8 years). PTSD symptoms measured using the PTSD Checklist (PCL) were assessed after 6 months of combat training but before deployment and again after 6 months of combat (Ns = 910 and 725 at pre-deployment and post-combat, respectively)Results Stronger connectivity between PTSD symptoms was observed post-combat relative to pre-deployment (global strength values of the networks were 7.54 pre v. 7.92 post; S =.38, p < 0.05). Both the re-experiencing symptoms cluster (1.92 v. 2.12; S =.20, p < 0.03) and the avoidance symptoms cluster (2.61 v. 2.96; S =.35, p < 0.005) became more strongly inter-correlated post-combat. Centrality estimation analyses revealed that psychological reaction to triggers was central and linked the intrusion and avoidance sub-clusters at post-combat. The strength of associations between the arousal and reactivity symptoms cluster remained stable over time (1.85 v. 1.83; S =.02, p =.92).Conclusions Following combat, PTSD symptoms and particularly the re-experiencing and avoidance clusters become more strongly inter-correlated, indicating high centrality of trigger-reactivity symptoms.

Original languageEnglish
Pages (from-to)746-753
Number of pages8
JournalPsychological Medicine
Issue number5
StatePublished - 1 Apr 2020


FundersFunder number
National Institute of Mental HealthZIAMH002781
Israel Science Foundation1811/17


    • Combat stress
    • Networks analysis
    • Post-traumatic stress disorder


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