Changes in the concentration of insulin-like growth factor I and transforming growth factor β1 in rat femoral bone during growth

J. Pfeilschifter, J. Erdmann, S. Storch, R. Ziegler, M. Weinreb

Research output: Contribution to journalArticlepeer-review

Abstract

Our knowledge of the concentration of growth factors in growing bone is limited. In the present study, we examined the developmental changes in the concentrations of insulin-like growth factor I (IGF-I) and transforming growth factor beta (TGF-β) in the rat femur between weanling and maturity. We show that during the rapid growth phase there is a continuous rise in bone matrix IGF-I and TGFβ in all compartments of the femoral bone. The association between IGF-I and TGF-β is not only temporal, but with few exceptions is also observed within the animals of each age class. These data support the hypothesis that IGF-I and TGF-β play an important role in the growth-associated accumulation of bone mass.

Original languageEnglish
Pages (from-to)78-82
Number of pages5
JournalCalcified Tissue International
Volume64
Issue number1
DOIs
StatePublished - 1999

Keywords

  • Bone matrix
  • Growth
  • Insulin-like growth factor-I
  • Rat
  • Transforming growth factor-β

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