Changes in the concentration of insulin-like growth factor I and transforming growth factor β1 in rat femoral bone during growth

J. Pfeilschifter; J. Erdmann; S. Storch; R. Ziegler; M. Weinreb

doi:10.1007/s002239900582

Changes in the concentration of insulin-like growth factor I and transforming growth factor β1 in rat femoral bone during growth

J. Pfeilschifter, J. Erdmann, S. Storch, R. Ziegler, M. Weinreb

School of Dentistry

Research output: Contribution to journal › Article › peer-review

Abstract

Our knowledge of the concentration of growth factors in growing bone is limited. In the present study, we examined the developmental changes in the concentrations of insulin-like growth factor I (IGF-I) and transforming growth factor beta (TGF-β) in the rat femur between weanling and maturity. We show that during the rapid growth phase there is a continuous rise in bone matrix IGF-I and TGFβ in all compartments of the femoral bone. The association between IGF-I and TGF-β is not only temporal, but with few exceptions is also observed within the animals of each age class. These data support the hypothesis that IGF-I and TGF-β play an important role in the growth-associated accumulation of bone mass.

Original language	English
Pages (from-to)	78-82
Number of pages	5
Journal	Calcified Tissue International
Volume	64
Issue number	1
DOIs	https://doi.org/10.1007/s002239900582
State	Published - 1999

Keywords

Bone matrix
Growth
Insulin-like growth factor-I
Rat
Transforming growth factor-β

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s002239900582

Cite this

@article{c635f01a585b41cb978ff9a62017947c,

title = "Changes in the concentration of insulin-like growth factor I and transforming growth factor β1 in rat femoral bone during growth",

abstract = "Our knowledge of the concentration of growth factors in growing bone is limited. In the present study, we examined the developmental changes in the concentrations of insulin-like growth factor I (IGF-I) and transforming growth factor beta (TGF-β) in the rat femur between weanling and maturity. We show that during the rapid growth phase there is a continuous rise in bone matrix IGF-I and TGFβ in all compartments of the femoral bone. The association between IGF-I and TGF-β is not only temporal, but with few exceptions is also observed within the animals of each age class. These data support the hypothesis that IGF-I and TGF-β play an important role in the growth-associated accumulation of bone mass.",

keywords = "Bone matrix, Growth, Insulin-like growth factor-I, Rat, Transforming growth factor-β",

author = "J. Pfeilschifter and J. Erdmann and S. Storch and R. Ziegler and M. Weinreb",

year = "1999",

doi = "10.1007/s002239900582",

language = "אנגלית",

volume = "64",

pages = "78--82",

journal = "Calcified Tissue International",

issn = "0171-967X",

publisher = "Springer New York",

number = "1",

}

TY - JOUR

T1 - Changes in the concentration of insulin-like growth factor I and transforming growth factor β1 in rat femoral bone during growth

AU - Pfeilschifter, J.

AU - Erdmann, J.

AU - Storch, S.

AU - Ziegler, R.

AU - Weinreb, M.

PY - 1999

Y1 - 1999

N2 - Our knowledge of the concentration of growth factors in growing bone is limited. In the present study, we examined the developmental changes in the concentrations of insulin-like growth factor I (IGF-I) and transforming growth factor beta (TGF-β) in the rat femur between weanling and maturity. We show that during the rapid growth phase there is a continuous rise in bone matrix IGF-I and TGFβ in all compartments of the femoral bone. The association between IGF-I and TGF-β is not only temporal, but with few exceptions is also observed within the animals of each age class. These data support the hypothesis that IGF-I and TGF-β play an important role in the growth-associated accumulation of bone mass.

AB - Our knowledge of the concentration of growth factors in growing bone is limited. In the present study, we examined the developmental changes in the concentrations of insulin-like growth factor I (IGF-I) and transforming growth factor beta (TGF-β) in the rat femur between weanling and maturity. We show that during the rapid growth phase there is a continuous rise in bone matrix IGF-I and TGFβ in all compartments of the femoral bone. The association between IGF-I and TGF-β is not only temporal, but with few exceptions is also observed within the animals of each age class. These data support the hypothesis that IGF-I and TGF-β play an important role in the growth-associated accumulation of bone mass.

KW - Bone matrix

KW - Growth

KW - Insulin-like growth factor-I

KW - Rat

KW - Transforming growth factor-β

UR - http://www.scopus.com/inward/record.url?scp=0032943559&partnerID=8YFLogxK

U2 - 10.1007/s002239900582

DO - 10.1007/s002239900582

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:0032943559

VL - 64

SP - 78

EP - 82

JO - Calcified Tissue International

JF - Calcified Tissue International

SN - 0171-967X

IS - 1

ER -

Changes in the concentration of insulin-like growth factor I and transforming growth factor β1 in rat femoral bone during growth

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this