Changes in High-Frequency Intracardiac Electrogram Indicate Cardiac Ischemia

Noam Omer*, Elad Bergman, Tamir Ben-David, Shimmy Huri, Amir Beker, Shimon Abboud, Yair Granot, David Meerkin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


High-frequency QRS (HFQRS) analysis of surface ECG is a reliable marker of cardiac ischemia (CI). This study aimed to assess the response of HFQRS signals from standard intracardiac electrodes (iHFQRS) to CI in swine and compare them with conventional ST-segment deviations. Devices with three intracardiac leads were implanted in three swine in a controlled environment. CI was induced by inflating a balloon in epicardial coronary arteries. A designated signal-processing algorithm was applied to quantify the iHFQRS content before, during, and after each occlusion. iHFQRS time responses were compared to conventional ST-segment deviations. Thirty-three over thirty-nine (85%) of the occlusions presented significant reduction in the iHFQRS signal, preceding ST-segment change, being the only indicator of CI in brief occlusions. iHFQRS was found to be an early indicator for the onset of CI and demonstrated superior sensitivity to conventional ST-segment deviations during brief ischemic episodes. Graphical abstract: [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)84-94
Number of pages11
JournalJournal of Cardiovascular Translational Research
Issue number1
StatePublished - Feb 2022


  • Cardiac ischemia
  • Electrogram
  • High-frequency ECG


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